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Type 1 diabetes-related autoantibodies are rare in Alaska native populations.

Mohatt, J; Gilliam, LK; Bekris, L; Ebbesson, S and Lernmark, Åke LU (2002) In Circumpolar Health Supplements 61(Feb). p.21-21
Abstract
OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like... (More)
OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Circumpolar Health Supplements
volume
61
issue
Feb
pages
21 - 21
publisher
International Association of Circumpolar Health Publishers
external identifiers
  • scopus:0036481342
ISSN
1797-2361
language
English
LU publication?
no
id
9ce06c8b-94a5-4e24-8fcd-e9c2c4135f95 (old id 1124816)
alternative location
http://ijch.fi/issues/611/611_Mohatt.pdf
date added to LUP
2008-05-27 14:57:54
date last changed
2017-10-22 03:52:08
@article{9ce06c8b-94a5-4e24-8fcd-e9c2c4135f95,
  abstract     = {OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco},
  author       = {Mohatt, J and Gilliam, LK and Bekris, L and Ebbesson, S and Lernmark, Åke},
  issn         = {1797-2361},
  language     = {eng},
  number       = {Feb},
  pages        = {21--21},
  publisher    = {International Association of Circumpolar Health Publishers},
  series       = {Circumpolar Health Supplements},
  title        = {Type 1 diabetes-related autoantibodies are rare in Alaska native populations.},
  volume       = {61},
  year         = {2002},
}