Type 1 diabetes-related autoantibodies are rare in Alaska native populations.
(2002) In International Journal of Circumpolar Health 61(1). p.21-31- Abstract
- OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like... (More)
- OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124816
- author
- Mohatt, J ; Gilliam, LK ; Bekris, L ; Ebbesson, S and Lernmark, Åke LU
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Circumpolar Health
- volume
- 61
- issue
- 1
- pages
- 21 - 31
- publisher
- International Journal of Circumpolar Health
- external identifiers
-
- scopus:0036481342
- ISSN
- 2242-3982
- DOI
- 10.3402/ijch.v61i0.17402
- language
- English
- LU publication?
- no
- id
- 9ce06c8b-94a5-4e24-8fcd-e9c2c4135f95 (old id 1124816)
- alternative location
- https://www.tandfonline.com/doi/abs/10.3402/ijch.v61i0.17402
- date added to LUP
- 2016-04-01 12:23:11
- date last changed
- 2022-02-26 06:22:23
@article{9ce06c8b-94a5-4e24-8fcd-e9c2c4135f95, abstract = {{OBJECTIVES: When clinical data were initially gathered from the Alaskan Eskimos in the 1950's, diabetes mellitus was noted to be quite rare. The prevalence of diabetes has increased significantly since that time, with rates of 10% reported recently in some Alaska native populations. Our goal was to understand the pathogenesis of diabetes among these groups, with the hypothesis that Alaskan Eskimos were predominantly affected by type 2 diabetes, not by latent autoimmune diabetes in adults (LADA). STUDY DESIGN: Population based case control study METHODS: We tested sera from subjects in two Eskimo villages for the presence of type 1 diabetes-related autoantibodies against glutamic acid decarboxylase (GAD65Ab) and tyrosine phosphatase-like islet antigen-2 (IA-2Ab). RESULTS: Among subjects from one Inupiat village (#1) and one SiberianYup'ik village (#2), there were 21 subjects with diabetes mellitus (DM), 17 with impaired glucose tolerance (IGT), and 226 healthy controls with normal gluco}}, author = {{Mohatt, J and Gilliam, LK and Bekris, L and Ebbesson, S and Lernmark, Åke}}, issn = {{2242-3982}}, language = {{eng}}, number = {{1}}, pages = {{21--31}}, publisher = {{International Journal of Circumpolar Health}}, series = {{International Journal of Circumpolar Health}}, title = {{Type 1 diabetes-related autoantibodies are rare in Alaska native populations.}}, url = {{http://dx.doi.org/10.3402/ijch.v61i0.17402}}, doi = {{10.3402/ijch.v61i0.17402}}, volume = {{61}}, year = {{2002}}, }