Advanced

Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.

Simonson, W; Ramanathan, S; Bieg, S; Poussier, P and Lernmark, Åke LU (2002) In Metabolism 51(5). p.569-574
Abstract
Dietary factors have been reported to affect the development of spontaneous diabetes in various colonies of inbred and outbred diabetes-prone (DP) BioBreeding (BB) rats. Several studies have attributed a protective effect to a diet omitting crude protein mixtures in favor of purified casein, hydrolyzed casein, or free amino acids. We have used inbred BB rats, all of which become diabetic in specific pathogen-free (SPF) conditions when fed ordinary rat chow, to test the capacity of 2 different protein-free diets to modulate BB rat diabetes in 2 distinct pathogen-free environments. BB rats known to all develop diabetes by 100 days of age were fed from birth with 1 of 3 diets. By 120 days of age, 100% of the animals on a standard diabetogenic... (More)
Dietary factors have been reported to affect the development of spontaneous diabetes in various colonies of inbred and outbred diabetes-prone (DP) BioBreeding (BB) rats. Several studies have attributed a protective effect to a diet omitting crude protein mixtures in favor of purified casein, hydrolyzed casein, or free amino acids. We have used inbred BB rats, all of which become diabetic in specific pathogen-free (SPF) conditions when fed ordinary rat chow, to test the capacity of 2 different protein-free diets to modulate BB rat diabetes in 2 distinct pathogen-free environments. BB rats known to all develop diabetes by 100 days of age were fed from birth with 1 of 3 diets. By 120 days of age, 100% of the animals on a standard diabetogenic chow diet, 83% of animals on an amino acid-based protein-free diet, and 100% of animals on a hydrolyzed casein-based diet had developed diabetes (P >.05). A slight delay in the age of onset was observed among rats fed the amino acid-based diet, but t (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Metabolism
volume
51
issue
5
pages
569 - 574
publisher
Elsevier
external identifiers
  • Scopus:0036256865
DOI
10.1053/meta.2002.31979
language
English
LU publication?
no
id
3baef55f-7275-496d-9ba8-037bc4ba05a2 (old id 1124820)
date added to LUP
2008-06-02 12:17:11
date last changed
2017-01-01 07:58:45
@article{3baef55f-7275-496d-9ba8-037bc4ba05a2,
  abstract     = {Dietary factors have been reported to affect the development of spontaneous diabetes in various colonies of inbred and outbred diabetes-prone (DP) BioBreeding (BB) rats. Several studies have attributed a protective effect to a diet omitting crude protein mixtures in favor of purified casein, hydrolyzed casein, or free amino acids. We have used inbred BB rats, all of which become diabetic in specific pathogen-free (SPF) conditions when fed ordinary rat chow, to test the capacity of 2 different protein-free diets to modulate BB rat diabetes in 2 distinct pathogen-free environments. BB rats known to all develop diabetes by 100 days of age were fed from birth with 1 of 3 diets. By 120 days of age, 100% of the animals on a standard diabetogenic chow diet, 83% of animals on an amino acid-based protein-free diet, and 100% of animals on a hydrolyzed casein-based diet had developed diabetes (P >.05). A slight delay in the age of onset was observed among rats fed the amino acid-based diet, but t},
  author       = {Simonson, W and Ramanathan, S and Bieg, S and Poussier, P and Lernmark, Åke},
  language     = {eng},
  number       = {5},
  pages        = {569--574},
  publisher    = {Elsevier},
  series       = {Metabolism},
  title        = {Protein-free diets do not protect high-incidence diabetes-prone BioBreeding rats from diabetes.},
  url          = {http://dx.doi.org/10.1053/meta.2002.31979},
  volume       = {51},
  year         = {2002},
}