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GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.

Maioli, Mario; Tonolo, G; Bekris, L; Cirillo, R; Schranz, D; Cossu, E; Ciccarese, M; Lernmark, Åke LU and , (2002) In Diabetes Research and Clinical Practice 56(1). p.41-47
Abstract
Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80... (More)
Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Research and Clinical Practice
volume
56
issue
1
pages
41 - 47
publisher
Elsevier
external identifiers
  • scopus:0036176006
ISSN
1872-8227
DOI
10.1016/S0168-8227(01)00348-5
language
English
LU publication?
no
id
a8330bb0-c77a-4683-b399-e8fe5fef0b10 (old id 1124832)
date added to LUP
2008-05-27 12:32:35
date last changed
2017-01-01 05:09:30
@article{a8330bb0-c77a-4683-b399-e8fe5fef0b10,
  abstract     = {Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r},
  author       = {Maioli, Mario and Tonolo, G and Bekris, L and Cirillo, R and Schranz, D and Cossu, E and Ciccarese, M and Lernmark, Åke and , },
  issn         = {1872-8227},
  language     = {eng},
  number       = {1},
  pages        = {41--47},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.},
  url          = {http://dx.doi.org/10.1016/S0168-8227(01)00348-5},
  volume       = {56},
  year         = {2002},
}