GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.
Maioli, Mario ; Tonolo, G ; Bekris, L ; Cirillo, R ; Schranz, D ; Cossu, E ; Ciccarese, M and Lernmark, Åke LU
(2002)
In Diabetes Research and Clinical Practice
56(1).
p.41-47
- Abstract
- Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80... (More)
- Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1124832
- author
- Maioli, Mario
; Tonolo, G
; Bekris, L
; Cirillo, R
; Schranz, D
; Cossu, E
; Ciccarese, M
and Lernmark, Åke
LU
- author collaboration
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Research and Clinical Practice
- volume
- 56
- issue
- 1
- pages
- 41 - 47
- publisher
- Elsevier
- external identifiers
-
- scopus:0036176006
- ISSN
- 1872-8227
- DOI
- 10.1016/S0168-8227(01)00348-5
- language
- English
- LU publication?
- no
- id
- a8330bb0-c77a-4683-b399-e8fe5fef0b10 (old id 1124832)
- date added to LUP
- 2016-04-01 12:27:22
- date last changed
- 2022-02-26 07:16:56
@article{a8330bb0-c77a-4683-b399-e8fe5fef0b10,
abstract = {{Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r}},
author = {{Maioli, Mario and Tonolo, G and Bekris, L and Cirillo, R and Schranz, D and Cossu, E and Ciccarese, M and Lernmark, Åke}},
issn = {{1872-8227}},
language = {{eng}},
number = {{1}},
pages = {{41--47}},
publisher = {{Elsevier}},
series = {{Diabetes Research and Clinical Practice}},
title = {{GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.}},
url = {{http://dx.doi.org/10.1016/S0168-8227(01)00348-5}},
doi = {{10.1016/S0168-8227(01)00348-5}},
volume = {{56}},
year = {{2002}},
}