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Decreasing rate of fatty involution at screening mammography

Blane, Caroline E; Fitzgerald, J Thomas; Gruppen, Larry D; Oh, Mary S; Helvie, Mark A and Andersson, Ingvar LU (2002) In Academic Radiology 9(8). p.895-898
Abstract
RATIONALE AND OBJECTIVES: This study was performed to document the perceived decrease in fatty involution at screening mammography during the past decade and evaluate the influence of hormone replacement therapy (HRT). MATERIALS AND METHODS: In December 1996, the mammograms of 261 consecutive screening patients with a comparison study obtained 5 years earlier were evaluated, and their breasts were categorized according to Breast Imaging Reporting and Data System categories for breast density. The women, aged 50-59 years, included 119 who had been receiving HRT for 0.25-15 years (mean, 3 years). From the files, 261 age-matched screening mammograms from 1986 were obtained; these patients also had comparison mammograms from 1981. Analysis of... (More)
RATIONALE AND OBJECTIVES: This study was performed to document the perceived decrease in fatty involution at screening mammography during the past decade and evaluate the influence of hormone replacement therapy (HRT). MATERIALS AND METHODS: In December 1996, the mammograms of 261 consecutive screening patients with a comparison study obtained 5 years earlier were evaluated, and their breasts were categorized according to Breast Imaging Reporting and Data System categories for breast density. The women, aged 50-59 years, included 119 who had been receiving HRT for 0.25-15 years (mean, 3 years). From the files, 261 age-matched screening mammograms from 1986 were obtained; these patients also had comparison mammograms from 1981. Analysis of variance was used to determine differences between the 1980s group, the 1990s group receiving HRT, and the 1990s group not receiving HRT. Scheffe tests were used for post hoc comparisons. Stepwise regression analysis was used to evaluate the relative influence of age, decade, score of the first mammogram, and HRT. RESULTS: Breast density for the 1991 mammograms did not differ significantly from that in 1981 (P < .05). Initial breast density was the best predictor of final breast density in both decades (P < .001), regardless of HRT status. The change in breast density (toward fatty) over the 5-year interval in the 1980s (mean, 0.48) was significantly greater than that in both 1990s groups (mean for HRT group, 0.11; no HRT, 0.30; P < .05). CONCLUSION: These results confirm that breast density at screening mammography in the 1990s did not decrease with age at the same rate as in the 1980s, even in patients not receiving HRT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Academic Radiology
volume
9
issue
8
pages
895 - 898
publisher
Elsevier
external identifiers
  • pmid:12186437
  • scopus:0035991785
ISSN
1878-4046
DOI
10.1016/S1076-6332(03)80458-0
language
English
LU publication?
yes
id
83997792-5725-448f-a5b6-4b90e490cc74 (old id 1125048)
date added to LUP
2008-05-19 12:44:04
date last changed
2017-01-01 06:48:39
@article{83997792-5725-448f-a5b6-4b90e490cc74,
  abstract     = {RATIONALE AND OBJECTIVES: This study was performed to document the perceived decrease in fatty involution at screening mammography during the past decade and evaluate the influence of hormone replacement therapy (HRT). MATERIALS AND METHODS: In December 1996, the mammograms of 261 consecutive screening patients with a comparison study obtained 5 years earlier were evaluated, and their breasts were categorized according to Breast Imaging Reporting and Data System categories for breast density. The women, aged 50-59 years, included 119 who had been receiving HRT for 0.25-15 years (mean, 3 years). From the files, 261 age-matched screening mammograms from 1986 were obtained; these patients also had comparison mammograms from 1981. Analysis of variance was used to determine differences between the 1980s group, the 1990s group receiving HRT, and the 1990s group not receiving HRT. Scheffe tests were used for post hoc comparisons. Stepwise regression analysis was used to evaluate the relative influence of age, decade, score of the first mammogram, and HRT. RESULTS: Breast density for the 1991 mammograms did not differ significantly from that in 1981 (P &lt; .05). Initial breast density was the best predictor of final breast density in both decades (P &lt; .001), regardless of HRT status. The change in breast density (toward fatty) over the 5-year interval in the 1980s (mean, 0.48) was significantly greater than that in both 1990s groups (mean for HRT group, 0.11; no HRT, 0.30; P &lt; .05). CONCLUSION: These results confirm that breast density at screening mammography in the 1990s did not decrease with age at the same rate as in the 1980s, even in patients not receiving HRT.},
  author       = {Blane, Caroline E and Fitzgerald, J Thomas and Gruppen, Larry D and Oh, Mary S and Helvie, Mark A and Andersson, Ingvar},
  issn         = {1878-4046},
  language     = {eng},
  number       = {8},
  pages        = {895--898},
  publisher    = {Elsevier},
  series       = {Academic Radiology},
  title        = {Decreasing rate of fatty involution at screening mammography},
  url          = {http://dx.doi.org/10.1016/S1076-6332(03)80458-0},
  volume       = {9},
  year         = {2002},
}