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Plasma oxidized LDL: a predictor for acute myocardial infarction?

Nordin Fredrikson, Gunilla LU ; Hedblad, Bo LU ; Berglund, Göran LU and Nilsson, J (2003) In Journal of Internal Medicine1989-01-01+01:00 253(4). p.425-429
Abstract
Objectives. Oxidized LDL has been attributed a key role in the development of atherosclerosis. Previous studies have demonstrated increased plasma levels of oxidized LDL in patients with established coronary artery disease. The aim of the present study was to investigate if plasma oxidized LDL also predicts risk for development of coronary heart disease (CHD).



Design. We used a nested case-control design to study the association between plasma levels of oxidized LDL and risk for development of acute myocardial infarction (AMI) and/or death by CHD.



Subjects. Oxidized LDL was analysed by ELISA in cases (n = 26), controls (n = 26) and controls with LDL cholesterol >5.0 mmol L-1 (n = 26).

... (More)
Objectives. Oxidized LDL has been attributed a key role in the development of atherosclerosis. Previous studies have demonstrated increased plasma levels of oxidized LDL in patients with established coronary artery disease. The aim of the present study was to investigate if plasma oxidized LDL also predicts risk for development of coronary heart disease (CHD).



Design. We used a nested case-control design to study the association between plasma levels of oxidized LDL and risk for development of acute myocardial infarction (AMI) and/or death by CHD.



Subjects. Oxidized LDL was analysed by ELISA in cases (n = 26), controls (n = 26) and controls with LDL cholesterol >5.0 mmol L-1 (n = 26).



Results. Oxidized LDL correlated with total plasma and LDL cholesterol in both cases (r = 0.72, P < 0.01, r = 0.69, P < 0.01, respectively) and controls (r = 0.71, P < 0.01, r = 0.77, P < 0.01, respectively). The oxidized LDL/plasma cholesterol ratio was higher amongst cases (13.5, range 10.7-19.8) than in controls (12.6, range 9.5-15.8, P < 0.05) and hypercholesterolaemic controls (12.2, range 8.0-16.0, P < 0.01).



Conclusions. These findings identify high plasma oxidized LDL/total cholesterol ratio as a possible indicator of increased risk for AMI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine1989-01-01+01:00
volume
253
issue
4
pages
425 - 429
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • pmid:12653871
  • wos:000181739700005
  • scopus:0037388739
ISSN
1365-2796
DOI
10.1046/j.1365-2796.2003.01128.x
language
English
LU publication?
yes
id
b928b034-8c8c-44f3-a330-adc8dfd18c4b (old id 112524)
date added to LUP
2007-07-27 11:10:31
date last changed
2018-10-14 04:02:13
@article{b928b034-8c8c-44f3-a330-adc8dfd18c4b,
  abstract     = {Objectives. Oxidized LDL has been attributed a key role in the development of atherosclerosis. Previous studies have demonstrated increased plasma levels of oxidized LDL in patients with established coronary artery disease. The aim of the present study was to investigate if plasma oxidized LDL also predicts risk for development of coronary heart disease (CHD).<br/><br>
<br/><br>
Design. We used a nested case-control design to study the association between plasma levels of oxidized LDL and risk for development of acute myocardial infarction (AMI) and/or death by CHD.<br/><br>
<br/><br>
Subjects. Oxidized LDL was analysed by ELISA in cases (n = 26), controls (n = 26) and controls with LDL cholesterol &gt;5.0 mmol L-1 (n = 26).<br/><br>
<br/><br>
Results. Oxidized LDL correlated with total plasma and LDL cholesterol in both cases (r = 0.72, P &lt; 0.01, r = 0.69, P &lt; 0.01, respectively) and controls (r = 0.71, P &lt; 0.01, r = 0.77, P &lt; 0.01, respectively). The oxidized LDL/plasma cholesterol ratio was higher amongst cases (13.5, range 10.7-19.8) than in controls (12.6, range 9.5-15.8, P &lt; 0.05) and hypercholesterolaemic controls (12.2, range 8.0-16.0, P &lt; 0.01).<br/><br>
<br/><br>
Conclusions. These findings identify high plasma oxidized LDL/total cholesterol ratio as a possible indicator of increased risk for AMI.},
  author       = {Nordin Fredrikson, Gunilla and Hedblad, Bo and Berglund, Göran and Nilsson, J},
  issn         = {1365-2796},
  language     = {eng},
  number       = {4},
  pages        = {425--429},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine1989-01-01+01:00},
  title        = {Plasma oxidized LDL: a predictor for acute myocardial infarction?},
  url          = {http://dx.doi.org/10.1046/j.1365-2796.2003.01128.x},
  volume       = {253},
  year         = {2003},
}