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CD46 in meningococcal disease

Johansson, Linda; Rytkonen, Anne; Bergman, Peter; Albiger, Barbara LU ; Kallstrom, Helena; Hokfelt, Tomas; Agerberth, Birgitta; Cattaneo, Roberto and Jonsson, Ann-Beth (2003) In Science (New York, N.Y.) 301(5631). p.373-375
Abstract
The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against... (More)
The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Science (New York, N.Y.)
volume
301
issue
5631
pages
373 - 375
publisher
The American Association for the Advancement of Science
external identifiers
  • pmid:12869763
  • scopus:0038638484
ISSN
1095-9203
DOI
10.1126/science.1086476
language
English
LU publication?
no
id
db529046-558f-4630-b11b-07fc3b41b27b (old id 1126309)
date added to LUP
2008-06-11 12:58:42
date last changed
2017-09-17 07:35:51
@article{db529046-558f-4630-b11b-07fc3b41b27b,
  abstract     = {The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease.},
  author       = {Johansson, Linda and Rytkonen, Anne and Bergman, Peter and Albiger, Barbara and Kallstrom, Helena and Hokfelt, Tomas and Agerberth, Birgitta and Cattaneo, Roberto and Jonsson, Ann-Beth},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5631},
  pages        = {373--375},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science (New York, N.Y.)},
  title        = {CD46 in meningococcal disease},
  url          = {http://dx.doi.org/10.1126/science.1086476},
  volume       = {301},
  year         = {2003},
}