Advanced

Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

Sørensen, Ole E LU ; Cowland, Jack B; Theilgaard-Monch, Kim; Liu, Lide; Ganz, Tomas and Borregaard, Niels (2003) In Journal of Immunology 170(11). p.5583-5589
Abstract
In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are produced to stimulate the regeneration of tissue. The growth factor response ceases after regeneration of the tissue, when the physical barrier protecting against microbial infections is re-established. We found that the growth factors important in wound healing, insulin-like growth factor I and TGF-alpha, induce the expression of the antimicrobial peptides/polypeptides human cationic antimicrobial protein hCAP-18/LL-37, human beta-defensin 3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor in human keratinocytes. Both an individual and a... (More)
In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are produced to stimulate the regeneration of tissue. The growth factor response ceases after regeneration of the tissue, when the physical barrier protecting against microbial infections is re-established. We found that the growth factors important in wound healing, insulin-like growth factor I and TGF-alpha, induce the expression of the antimicrobial peptides/polypeptides human cationic antimicrobial protein hCAP-18/LL-37, human beta-defensin 3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor in human keratinocytes. Both an individual and a synergistic effect of these growth factors were observed. These findings offer an explanation for the expression of these peptides/polypeptides in the skin disease psoriasis and in wound healing and define a host defense role for growth factors in wound healing. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
170
issue
11
pages
5583 - 5589
publisher
American Association of Immunologists
external identifiers
  • pmid:12759437
  • scopus:0038189571
ISSN
1550-6606
language
English
LU publication?
yes
id
2196bab9-bfed-4db1-b16b-6b75d540e83d (old id 1126338)
date added to LUP
2008-06-11 12:33:57
date last changed
2018-10-03 10:25:15
@article{2196bab9-bfed-4db1-b16b-6b75d540e83d,
  abstract     = {In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are produced to stimulate the regeneration of tissue. The growth factor response ceases after regeneration of the tissue, when the physical barrier protecting against microbial infections is re-established. We found that the growth factors important in wound healing, insulin-like growth factor I and TGF-alpha, induce the expression of the antimicrobial peptides/polypeptides human cationic antimicrobial protein hCAP-18/LL-37, human beta-defensin 3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor in human keratinocytes. Both an individual and a synergistic effect of these growth factors were observed. These findings offer an explanation for the expression of these peptides/polypeptides in the skin disease psoriasis and in wound healing and define a host defense role for growth factors in wound healing.},
  author       = {Sørensen, Ole E and Cowland, Jack B and Theilgaard-Monch, Kim and Liu, Lide and Ganz, Tomas and Borregaard, Niels},
  issn         = {1550-6606},
  language     = {eng},
  number       = {11},
  pages        = {5583--5589},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors},
  volume       = {170},
  year         = {2003},
}