DAK, a new low-incidence antigen in the Rh blood group system
(2003) In Transfusion 43(10). p.1394-1397- Abstract
- BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could... (More)
- BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION: An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1126502
- author
- Reid, Marion E ; Storry, Jill LU ; Sausais, Laima ; Tossas, Edith ; Rios, Maria ; Hue-Roye, Kim ; Gloster, Elizabeth S ; Miller, Scott T ; Wolf, Carl and Lomas-Francis, Christine
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Transfusion
- volume
- 43
- issue
- 10
- pages
- 1394 - 1397
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:14507270
- scopus:0142135468
- ISSN
- 1537-2995
- DOI
- 10.1046/j.1537-2995.2003.00517.x
- language
- English
- LU publication?
- no
- id
- 60ab5664-8a67-4ced-a965-6bb6a4cc9859 (old id 1126502)
- date added to LUP
- 2016-04-01 16:58:46
- date last changed
- 2022-01-28 23:28:34
@article{60ab5664-8a67-4ced-a965-6bb6a4cc9859, abstract = {{BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION: An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054).}}, author = {{Reid, Marion E and Storry, Jill and Sausais, Laima and Tossas, Edith and Rios, Maria and Hue-Roye, Kim and Gloster, Elizabeth S and Miller, Scott T and Wolf, Carl and Lomas-Francis, Christine}}, issn = {{1537-2995}}, language = {{eng}}, number = {{10}}, pages = {{1394--1397}}, publisher = {{Wiley-Blackwell}}, series = {{Transfusion}}, title = {{DAK, a new low-incidence antigen in the Rh blood group system}}, url = {{http://dx.doi.org/10.1046/j.1537-2995.2003.00517.x}}, doi = {{10.1046/j.1537-2995.2003.00517.x}}, volume = {{43}}, year = {{2003}}, }