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DAK, a new low-incidence antigen in the Rh blood group system

Reid, Marion E; Storry, Jill LU ; Sausais, Laima; Tossas, Edith; Rios, Maria; Hue-Roye, Kim; Gloster, Elizabeth S; Miller, Scott T; Wolf, Carl and Lomas-Francis, Christine (2003) In Transfusion 43(10). p.1394-1397
Abstract
BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could... (More)
BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION: An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054). (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Transfusion
volume
43
issue
10
pages
1394 - 1397
publisher
Wiley-Blackwell
external identifiers
  • pmid:14507270
  • scopus:0142135468
ISSN
1537-2995
DOI
10.1046/j.1537-2995.2003.00517.x
language
English
LU publication?
no
id
60ab5664-8a67-4ced-a965-6bb6a4cc9859 (old id 1126502)
date added to LUP
2008-06-11 10:39:00
date last changed
2018-01-07 09:40:24
@article{60ab5664-8a67-4ced-a965-6bb6a4cc9859,
  abstract     = {BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION: An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054).},
  author       = {Reid, Marion E and Storry, Jill and Sausais, Laima and Tossas, Edith and Rios, Maria and Hue-Roye, Kim and Gloster, Elizabeth S and Miller, Scott T and Wolf, Carl and Lomas-Francis, Christine},
  issn         = {1537-2995},
  language     = {eng},
  number       = {10},
  pages        = {1394--1397},
  publisher    = {Wiley-Blackwell},
  series       = {Transfusion},
  title        = {DAK, a new low-incidence antigen in the Rh blood group system},
  url          = {http://dx.doi.org/10.1046/j.1537-2995.2003.00517.x},
  volume       = {43},
  year         = {2003},
}