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Inhibition of Atherosclerosis in ApoE-Null Mice by Immunization with ApoB-100 Peptide Sequences.

Nordin Fredrikson, Gunilla LU ; Söderberg, Ingrid LU ; Lindholm, Marie LU ; Dimayuga, Paul; Chyu, Kuang-Yuh; Shah, Prediman K. and Nilsson, Jan LU (2003) In Arteriosclerosis, Thrombosis and Vascular Biology 23(5). p.879-884
Abstract
Objective - LDL oxidation is believed to play an important role in the development of atherosclerosis, and oxidized LDL particles have been shown to become targets for the immune system. Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response. Methods and Results - Using a polypeptide library covering the complete sequence of apoB-100, a large number of native and malondialdehyde-modified peptide sequences in apoB-100 that are recognized by antibodies in human plasma were identified. We report here that immunization with apoB-100 peptide sequences, against which high levels of IgG and IgM antibodies are present in healthy human controls, reduce... (More)
Objective - LDL oxidation is believed to play an important role in the development of atherosclerosis, and oxidized LDL particles have been shown to become targets for the immune system. Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response. Methods and Results - Using a polypeptide library covering the complete sequence of apoB-100, a large number of native and malondialdehyde-modified peptide sequences in apoB-100 that are recognized by antibodies in human plasma were identified. We report here that immunization with apoB-100 peptide sequences, against which high levels of IgG and IgM antibodies are present in healthy human controls, reduce atherosclerosis in apoE-null mice by about 60%. Immunizations with these peptides were also found to increase the collagen content of subvalvular lesions. Conclusions - These studies have identified peptide sequences in apoB-100 that induce immune responses, which inhibits atherosclerosis. This suggests a way of developing an immunization therapy for coronary heart disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
peptides, immunization, apolipoproteins, atherosclerosis, mice
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
23
issue
5
pages
879 - 884
publisher
American Heart Association
external identifiers
  • wos:000182742500028
  • pmid:12649092
  • scopus:0038639407
ISSN
1524-4636
DOI
10.1161/01.ATV.0000067937.93716.DB
language
English
LU publication?
yes
id
98a1cfe6-d564-4054-9baf-c420b5ddf933 (old id 112654)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12649092&dopt=Abstract
date added to LUP
2007-07-27 11:29:38
date last changed
2018-10-14 03:30:26
@article{98a1cfe6-d564-4054-9baf-c420b5ddf933,
  abstract     = {Objective - LDL oxidation is believed to play an important role in the development of atherosclerosis, and oxidized LDL particles have been shown to become targets for the immune system. Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response. Methods and Results - Using a polypeptide library covering the complete sequence of apoB-100, a large number of native and malondialdehyde-modified peptide sequences in apoB-100 that are recognized by antibodies in human plasma were identified. We report here that immunization with apoB-100 peptide sequences, against which high levels of IgG and IgM antibodies are present in healthy human controls, reduce atherosclerosis in apoE-null mice by about 60%. Immunizations with these peptides were also found to increase the collagen content of subvalvular lesions. Conclusions - These studies have identified peptide sequences in apoB-100 that induce immune responses, which inhibits atherosclerosis. This suggests a way of developing an immunization therapy for coronary heart disease.},
  author       = {Nordin Fredrikson, Gunilla and Söderberg, Ingrid and Lindholm, Marie and Dimayuga, Paul and Chyu, Kuang-Yuh and Shah, Prediman K. and Nilsson, Jan},
  issn         = {1524-4636},
  keyword      = {peptides,immunization,apolipoproteins,atherosclerosis,mice},
  language     = {eng},
  number       = {5},
  pages        = {879--884},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Inhibition of Atherosclerosis in ApoE-Null Mice by Immunization with ApoB-100 Peptide Sequences.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000067937.93716.DB},
  volume       = {23},
  year         = {2003},
}