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Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women

Ford, Caroline LU ; Tran, Dinh; Deng, YiMo; Ta, Van To; Rawlinson, William D and Lawson, James S (2003) In Clinical Cancer Research 9(3). p.1118-1120
Abstract
PURPOSE: There is considerable evidence that the presence of mouse mammary tumor virus (MMTV)-like gene sequences in human breast cancer is highly associated with human breast carcinoma. Previous studies have found MMTV-like gene sequences in 38% of breast cancer tissue from United States women. The prevalence of these sequences in Australian and Vietnamese women has never been reported. EXPERIMENTAL DESIGN: Using PCR and primers that amplify MMTV-like gene sequences, we tested cancerous and benign breast tissue from Caucasian-Australian, Vietnamese-Australian, and Vietnamese women. RESULTS: MMTV-like gene sequences were amplified in 19 of 45 (42.2%) archival breast cancer biopsy tissues from Caucasian-Australian women, but only 1 of 120... (More)
PURPOSE: There is considerable evidence that the presence of mouse mammary tumor virus (MMTV)-like gene sequences in human breast cancer is highly associated with human breast carcinoma. Previous studies have found MMTV-like gene sequences in 38% of breast cancer tissue from United States women. The prevalence of these sequences in Australian and Vietnamese women has never been reported. EXPERIMENTAL DESIGN: Using PCR and primers that amplify MMTV-like gene sequences, we tested cancerous and benign breast tissue from Caucasian-Australian, Vietnamese-Australian, and Vietnamese women. RESULTS: MMTV-like gene sequences were amplified in 19 of 45 (42.2%) archival breast cancer biopsy tissues from Caucasian-Australian women, but only 1 of 120 (0.8%) and 0 of 41 breast cancer biopsy tissues from Vietnamese and Vietnamese-Australian women, respectively. The same sequences were found in only 2 of 111 (1.8%) and 0 of 60 normal (benign) breast tissue samples from Australian and Vietnamese women, respectively. CONCLUSIONS: MMTV-like gene sequences are found in only some human populations and are rarely found in normal human breast tissue from all populations, suggesting they are not present in the normal human genome and have been acquired. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Cancer Research
volume
9
issue
3
pages
1118 - 1120
publisher
American Association for Cancer Research
external identifiers
  • pmid:12631616
  • scopus:0037341584
ISSN
1078-0432
language
English
LU publication?
no
id
a37c69c9-528e-46fa-898c-5e6cb0142ad2 (old id 1127162)
alternative location
http://clincancerres.aacrjournals.org/content/9/3/1118.long
date added to LUP
2008-06-10 08:54:39
date last changed
2018-06-03 03:44:21
@article{a37c69c9-528e-46fa-898c-5e6cb0142ad2,
  abstract     = {PURPOSE: There is considerable evidence that the presence of mouse mammary tumor virus (MMTV)-like gene sequences in human breast cancer is highly associated with human breast carcinoma. Previous studies have found MMTV-like gene sequences in 38% of breast cancer tissue from United States women. The prevalence of these sequences in Australian and Vietnamese women has never been reported. EXPERIMENTAL DESIGN: Using PCR and primers that amplify MMTV-like gene sequences, we tested cancerous and benign breast tissue from Caucasian-Australian, Vietnamese-Australian, and Vietnamese women. RESULTS: MMTV-like gene sequences were amplified in 19 of 45 (42.2%) archival breast cancer biopsy tissues from Caucasian-Australian women, but only 1 of 120 (0.8%) and 0 of 41 breast cancer biopsy tissues from Vietnamese and Vietnamese-Australian women, respectively. The same sequences were found in only 2 of 111 (1.8%) and 0 of 60 normal (benign) breast tissue samples from Australian and Vietnamese women, respectively. CONCLUSIONS: MMTV-like gene sequences are found in only some human populations and are rarely found in normal human breast tissue from all populations, suggesting they are not present in the normal human genome and have been acquired.},
  author       = {Ford, Caroline and Tran, Dinh and Deng, YiMo and Ta, Van To and Rawlinson, William D and Lawson, James S},
  issn         = {1078-0432},
  language     = {eng},
  number       = {3},
  pages        = {1118--1120},
  publisher    = {American Association for Cancer Research},
  series       = {Clinical Cancer Research},
  title        = {Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women},
  volume       = {9},
  year         = {2003},
}