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Increased nitric oxide levels as an early sign of premature aging in diabetes

Stadler, Krisztian; Jenei, Veronica LU ; von Bolcshazy, Gabor; Somogyi, Aniko and Jakus, Judit (2003) In Free Radical Biology & Medicine 35(10). p.1240-1251
Abstract
The levels of different reactive species, especially those of nitric oxide and peroxynitrite, were determined in streptozotocin-induced diabetic rat tissues, before the development of histopathological damages. Significantly higher steady state free radical concentrations were found in the liver 3 weeks after the onset of diabetes compared to age-matched control groups. Increased nitric oxide levels in diabetic vasculature and kidney decreased the production of detectable reactive oxygen species. High peroxynitrite generation suggested the onset of processes characteristic to premature aging of the endothelium. According to the histopathological results, there were no signs of late complications in the tissues up to 7 weeks after induction... (More)
The levels of different reactive species, especially those of nitric oxide and peroxynitrite, were determined in streptozotocin-induced diabetic rat tissues, before the development of histopathological damages. Significantly higher steady state free radical concentrations were found in the liver 3 weeks after the onset of diabetes compared to age-matched control groups. Increased nitric oxide levels in diabetic vasculature and kidney decreased the production of detectable reactive oxygen species. High peroxynitrite generation suggested the onset of processes characteristic to premature aging of the endothelium. According to the histopathological results, there were no signs of late complications in the tissues up to 7 weeks after induction of diabetes. These results support the idea that oxidative stress is increased at a very early stage of diabetes and, in particular, that high levels of nitric oxide and peroxynitrite could play a decisive role in the development of late complications in the diabetic vasculature and kidney. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Free Radical Biology & Medicine
volume
35
issue
10
pages
1240 - 1251
publisher
Elsevier
external identifiers
  • pmid:14607523
  • scopus:0242352418
ISSN
0891-5849
DOI
10.1016/S0891-5849(03)00499-4
language
English
LU publication?
no
id
f7127f1e-7abc-4fc0-8e56-b32687fbe855 (old id 1127186)
date added to LUP
2008-06-10 09:08:25
date last changed
2018-08-05 03:27:03
@article{f7127f1e-7abc-4fc0-8e56-b32687fbe855,
  abstract     = {The levels of different reactive species, especially those of nitric oxide and peroxynitrite, were determined in streptozotocin-induced diabetic rat tissues, before the development of histopathological damages. Significantly higher steady state free radical concentrations were found in the liver 3 weeks after the onset of diabetes compared to age-matched control groups. Increased nitric oxide levels in diabetic vasculature and kidney decreased the production of detectable reactive oxygen species. High peroxynitrite generation suggested the onset of processes characteristic to premature aging of the endothelium. According to the histopathological results, there were no signs of late complications in the tissues up to 7 weeks after induction of diabetes. These results support the idea that oxidative stress is increased at a very early stage of diabetes and, in particular, that high levels of nitric oxide and peroxynitrite could play a decisive role in the development of late complications in the diabetic vasculature and kidney.},
  author       = {Stadler, Krisztian and Jenei, Veronica and von Bolcshazy, Gabor and Somogyi, Aniko and Jakus, Judit},
  issn         = {0891-5849},
  language     = {eng},
  number       = {10},
  pages        = {1240--1251},
  publisher    = {Elsevier},
  series       = {Free Radical Biology & Medicine},
  title        = {Increased nitric oxide levels as an early sign of premature aging in diabetes},
  url          = {http://dx.doi.org/10.1016/S0891-5849(03)00499-4},
  volume       = {35},
  year         = {2003},
}