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För tidigt att rekommendera allmän screening för kolorektal cancer

Ekelund, Göran LU and Janzon, Lars (2003) In Läkartidningen 100(38). p.2922-2926
Abstract
Randomised controlled trials have shown that screening may significantly reduce mortality in coloretcal cancer. In the present evaluation it is shown that the reported reduction of 15 per cent, or higher, is given in relative figures. With absolute figures the reduction is only 0.15 per cent or lower. The number of individuals needed to invite for screening (NNT) biannually for 10 years to prevent one death in colorectal cancer is 1,173 (confidence interval 741-2,807). Side-effects, costs and ethical issues are seldom, or never, discussed. Postopeative follow-up may be regardes as the screening of a high-risk group. The reduced mortality seen in the metaanalysis of randomised controlled trials is here regarded as small and should also be... (More)
Randomised controlled trials have shown that screening may significantly reduce mortality in coloretcal cancer. In the present evaluation it is shown that the reported reduction of 15 per cent, or higher, is given in relative figures. With absolute figures the reduction is only 0.15 per cent or lower. The number of individuals needed to invite for screening (NNT) biannually for 10 years to prevent one death in colorectal cancer is 1,173 (confidence interval 741-2,807). Side-effects, costs and ethical issues are seldom, or never, discussed. Postopeative follow-up may be regardes as the screening of a high-risk group. The reduced mortality seen in the metaanalysis of randomised controlled trials is here regarded as small and should also be weighed against the drawbacks of follow-up before any recommendation for more active surveillance is given. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
100
issue
38
pages
2922 - 2926
publisher
Swedish Medical Association
external identifiers
  • scopus:0242272515
ISSN
0023-7205
language
English
LU publication?
yes
id
ab2a6096-c390-47bd-b2a4-c688775c61bb (old id 1127219)
alternative location
http://ltarkiv.lakartidningen.se/artNo27191
date added to LUP
2008-06-09 14:07:50
date last changed
2018-01-07 08:43:56
@article{ab2a6096-c390-47bd-b2a4-c688775c61bb,
  abstract     = {Randomised controlled trials have shown that screening may significantly reduce mortality in coloretcal cancer. In the present evaluation it is shown that the reported reduction of 15 per cent, or higher, is given in relative figures. With absolute figures the reduction is only 0.15 per cent or lower. The number of individuals needed to invite for screening (NNT) biannually for 10 years to prevent one death in colorectal cancer is 1,173 (confidence interval 741-2,807). Side-effects, costs and ethical issues are seldom, or never, discussed. Postopeative follow-up may be regardes as the screening of a high-risk group. The reduced mortality seen in the metaanalysis of randomised controlled trials is here regarded as small and should also be weighed against the drawbacks of follow-up before any recommendation for more active surveillance is given.},
  author       = {Ekelund, Göran and Janzon, Lars},
  issn         = {0023-7205},
  language     = {eng},
  number       = {38},
  pages        = {2922--2926},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {För tidigt att rekommendera allmän screening för kolorektal cancer},
  volume       = {100},
  year         = {2003},
}