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Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media.

Liuba, Petru LU ; Persson, Jerker; Luoma, Jukka; Ylä-Herttuala, Seppo and Pesonen, Erkki LU (2003) In European Heart Journal 24(6). p.517-523
Abstract
Background Atherosclerosis begins early in life. Infections might contribute to the pathogenesis of atherosclerosis. In this study, we investigated whether acute infections in children could alter the carotid wall morphology and the tipid profile. Methods Mean carotid intima-media thickness (IMT) was measured by high-resolution ultrasound in 28 hospitatised children (mean age: 5 2 years), who fulfilled the diagnostic criteria of acute infections (body temperature, >38 degreesC; C-reactive protein, >15 mg/ml, and clinical), and in 20 age- and gender-matched controls. Antibodies against oxidised tow-density lipoprotein (anti-oxLDL antibodies), as well as total and high-density lipoprotein cholesterol (HDL-C) were analysed in all... (More)
Background Atherosclerosis begins early in life. Infections might contribute to the pathogenesis of atherosclerosis. In this study, we investigated whether acute infections in children could alter the carotid wall morphology and the tipid profile. Methods Mean carotid intima-media thickness (IMT) was measured by high-resolution ultrasound in 28 hospitatised children (mean age: 5 2 years), who fulfilled the diagnostic criteria of acute infections (body temperature, >38 degreesC; C-reactive protein, >15 mg/ml, and clinical), and in 20 age- and gender-matched controls. Antibodies against oxidised tow-density lipoprotein (anti-oxLDL antibodies), as well as total and high-density lipoprotein cholesterol (HDL-C) were analysed in all children. The infection group was investigated both during the acute illness and 3 months after clinical recovery (post-infection). Results During the acute illness, the infection group had elevated anti-oxLDL antibodies and decreased HDL-C, as compared to those obtained at 3 months and in controls (p<0.05). These changes in the infection group were followed, at 3 months, by thickening of carotid intima-media. Those who received antibiotics during their acute illness had less carotid thickening than those who were not treated with antibiotics (p<0.05). Conclusion Acute infections in children seem to be accompanied by enhanced oxidative modification of LDL and by decrease in HDL-C. These lipid changes may be followed by thickening of carotid artery intima-media. These findings suggest that, in childhood, acute infections could be-associated with increased risk of atherosclerosis, and warrant further studies on this topic. (C) 2003 The European Society of Cardiology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
high-density lipoprotein, oxidised low-density lipoprotein, acute infection, carotid intima-media thickness
in
European Heart Journal
volume
24
issue
6
pages
517 - 523
publisher
Oxford University Press
external identifiers
  • wos:000181813300008
  • scopus:0345354672
ISSN
1522-9645
DOI
10.1016/S0195-668X(02)00750-9
language
English
LU publication?
yes
id
c258a5b1-47b7-4f36-a176-32f11f5ef0dc (old id 112723)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12643884&dopt=Abstract
date added to LUP
2007-07-19 13:14:53
date last changed
2018-10-03 10:19:16
@article{c258a5b1-47b7-4f36-a176-32f11f5ef0dc,
  abstract     = {Background Atherosclerosis begins early in life. Infections might contribute to the pathogenesis of atherosclerosis. In this study, we investigated whether acute infections in children could alter the carotid wall morphology and the tipid profile. Methods Mean carotid intima-media thickness (IMT) was measured by high-resolution ultrasound in 28 hospitatised children (mean age: 5 2 years), who fulfilled the diagnostic criteria of acute infections (body temperature, &gt;38 degreesC; C-reactive protein, &gt;15 mg/ml, and clinical), and in 20 age- and gender-matched controls. Antibodies against oxidised tow-density lipoprotein (anti-oxLDL antibodies), as well as total and high-density lipoprotein cholesterol (HDL-C) were analysed in all children. The infection group was investigated both during the acute illness and 3 months after clinical recovery (post-infection). Results During the acute illness, the infection group had elevated anti-oxLDL antibodies and decreased HDL-C, as compared to those obtained at 3 months and in controls (p&lt;0.05). These changes in the infection group were followed, at 3 months, by thickening of carotid intima-media. Those who received antibiotics during their acute illness had less carotid thickening than those who were not treated with antibiotics (p&lt;0.05). Conclusion Acute infections in children seem to be accompanied by enhanced oxidative modification of LDL and by decrease in HDL-C. These lipid changes may be followed by thickening of carotid artery intima-media. These findings suggest that, in childhood, acute infections could be-associated with increased risk of atherosclerosis, and warrant further studies on this topic. (C) 2003 The European Society of Cardiology.},
  author       = {Liuba, Petru and Persson, Jerker and Luoma, Jukka and Ylä-Herttuala, Seppo and Pesonen, Erkki},
  issn         = {1522-9645},
  keyword      = {high-density lipoprotein,oxidised low-density lipoprotein,acute infection,carotid intima-media thickness},
  language     = {eng},
  number       = {6},
  pages        = {517--523},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media.},
  url          = {http://dx.doi.org/10.1016/S0195-668X(02)00750-9},
  volume       = {24},
  year         = {2003},
}