Advanced

GAD2 on chromosome 10p12 is a candidate gene for human obesity.

Boutin, Philippe; Dina, Christian; Vasseur, Francis; Dubois, Séverine; Corset, Laetitia; Séron, Karin; Bekris, Lynn; Cabellon, Janice; Neve, Bernadette and Vasseur-Delannoy, Valérie, et al. (2003) In PLoS Biology 1(3).
Abstract
The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese and 646 control subjects) analyzing GAD2 variants identified both a protective haplotype, including the most frequent alleles of single nucleotide polymorphisms (SNPs) +61450 C>A and +83897 T>A (OR = 0.81, 95% CI [0.681-0.972], p = 0.0049) and an at-risk SNP (-243 A>G) for morbid obesity (OR = 1.3, 95% CI... (More)
The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese and 646 control subjects) analyzing GAD2 variants identified both a protective haplotype, including the most frequent alleles of single nucleotide polymorphisms (SNPs) +61450 C>A and +83897 T>A (OR = 0.81, 95% CI [0.681-0.972], p = 0.0049) and an at-risk SNP (-243 A>G) for morbid obesity (OR = 1.3, 95% CI [1.053-1.585], p = 0.014). Furthermore, familial-based analyses confirmed the association with the obesity of SNP +61450 C>A and +83897 T>A haplotype (chi(2) = 7.637, p = 0.02). In the murine insulinoma cell line betaTC3, the G at-risk allele of SNP -243 A>G in (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Biology
volume
1
issue
3
publisher
Public Library of Science
external identifiers
  • scopus:2642512097
ISSN
1544-9173
DOI
language
English
LU publication?
no
id
249bf502-7ca5-4a32-af30-8eab136cebd9 (old id 1127385)
date added to LUP
2008-06-02 13:59:25
date last changed
2018-05-29 10:14:59
@article{249bf502-7ca5-4a32-af30-8eab136cebd9,
  abstract     = {The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese and 646 control subjects) analyzing GAD2 variants identified both a protective haplotype, including the most frequent alleles of single nucleotide polymorphisms (SNPs) +61450 C>A and +83897 T>A (OR = 0.81, 95% CI [0.681-0.972], p = 0.0049) and an at-risk SNP (-243 A>G) for morbid obesity (OR = 1.3, 95% CI [1.053-1.585], p = 0.014). Furthermore, familial-based analyses confirmed the association with the obesity of SNP +61450 C>A and +83897 T>A haplotype (chi(2) = 7.637, p = 0.02). In the murine insulinoma cell line betaTC3, the G at-risk allele of SNP -243 A>G in},
  articleno    = {68},
  author       = {Boutin, Philippe and Dina, Christian and Vasseur, Francis and Dubois, Séverine and Corset, Laetitia and Séron, Karin and Bekris, Lynn and Cabellon, Janice and Neve, Bernadette and Vasseur-Delannoy, Valérie and Chikri, Mohamed and Charles, M. Aline and Clement, Karine and Lernmark, Åke and Froguel, Philippe},
  issn         = {1544-9173},
  language     = {eng},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS Biology},
  title        = {GAD2 on chromosome 10p12 is a candidate gene for human obesity.},
  url          = {http://dx.doi.org/},
  volume       = {1},
  year         = {2003},
}