Day 3 versus day 5 embryo transfer: a prospective randomized study
(2003) In Reproductive BioMedicine Online 7(1). p.98-104- Abstract
- Transfer of embryos at the blastocyst stage has been associated with exceptionally high implantation rates. There are, however, only a few prospective randomized studies comparing day 3 versus day 5 embryo transfer. Furthermore, the number of embryos replaced in the day 3 group transfer is often higher than the number of blastocysts replaced, thereby affecting implantation rates. A total of 118 patients undergoing standard IVF/intracytoplasmic sperm injection who had developed at least three 8-cell embryos showing <20% extracellular fragmentation on day 3 were randomized for day 3 or day 5 transfer. A maximum of two embryos were replaced. In this prospective, randomized study the implantation and pregnancy potential of embryos... (More)
- Transfer of embryos at the blastocyst stage has been associated with exceptionally high implantation rates. There are, however, only a few prospective randomized studies comparing day 3 versus day 5 embryo transfer. Furthermore, the number of embryos replaced in the day 3 group transfer is often higher than the number of blastocysts replaced, thereby affecting implantation rates. A total of 118 patients undergoing standard IVF/intracytoplasmic sperm injection who had developed at least three 8-cell embryos showing <20% extracellular fragmentation on day 3 were randomized for day 3 or day 5 transfer. A maximum of two embryos were replaced. In this prospective, randomized study the implantation and pregnancy potential of embryos transferred on day 3 or day 5 were compared. Equal numbers of embryos were replaced in the two groups. There was no statistically significant difference between day 3 and day 5 transfer regarding positive human chorionic gonadotrophin rates (70 versus 67%), clinical pregnancy rates (61 versus 51%), implantation rates (44 versus 37%), twinning rates (42 versus 41%) and rates of early pregnancy loss (15 versus 29%). Transfer of embryos on day 3 or 5 showed similar implantation rates when equal numbers of embryos were transferred. Embryo transfer at the blastocyst stage seems to have no advantage over day 3 transfer in patients with more than two 8-cell embryos showing less than 20% fragmentation on day 3. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1127405
- author
- Bungum, Mona LU ; Bungum, L ; Humaidan, P and Yding Andersen, C
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive BioMedicine Online
- volume
- 7
- issue
- 1
- pages
- 98 - 104
- publisher
- Elsevier
- external identifiers
-
- pmid:12930586
- scopus:0038487112
- ISSN
- 1472-6491
- language
- English
- LU publication?
- no
- id
- 7f7ebcd4-6119-4759-9eef-ef5774ee554b (old id 1127405)
- date added to LUP
- 2016-04-01 11:44:19
- date last changed
- 2024-01-07 18:40:21
@article{7f7ebcd4-6119-4759-9eef-ef5774ee554b, abstract = {{Transfer of embryos at the blastocyst stage has been associated with exceptionally high implantation rates. There are, however, only a few prospective randomized studies comparing day 3 versus day 5 embryo transfer. Furthermore, the number of embryos replaced in the day 3 group transfer is often higher than the number of blastocysts replaced, thereby affecting implantation rates. A total of 118 patients undergoing standard IVF/intracytoplasmic sperm injection who had developed at least three 8-cell embryos showing <20% extracellular fragmentation on day 3 were randomized for day 3 or day 5 transfer. A maximum of two embryos were replaced. In this prospective, randomized study the implantation and pregnancy potential of embryos transferred on day 3 or day 5 were compared. Equal numbers of embryos were replaced in the two groups. There was no statistically significant difference between day 3 and day 5 transfer regarding positive human chorionic gonadotrophin rates (70 versus 67%), clinical pregnancy rates (61 versus 51%), implantation rates (44 versus 37%), twinning rates (42 versus 41%) and rates of early pregnancy loss (15 versus 29%). Transfer of embryos on day 3 or 5 showed similar implantation rates when equal numbers of embryos were transferred. Embryo transfer at the blastocyst stage seems to have no advantage over day 3 transfer in patients with more than two 8-cell embryos showing less than 20% fragmentation on day 3.}}, author = {{Bungum, Mona and Bungum, L and Humaidan, P and Yding Andersen, C}}, issn = {{1472-6491}}, language = {{eng}}, number = {{1}}, pages = {{98--104}}, publisher = {{Elsevier}}, series = {{Reproductive BioMedicine Online}}, title = {{Day 3 versus day 5 embryo transfer: a prospective randomized study}}, volume = {{7}}, year = {{2003}}, }