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Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland

Hedlund, G Persdotter; Carlsson, H E; Shieck, E; Nilsson, I; Lundblad, Cornelia LU ; Arons, S; Iversen, A K; Looman, C; Jensen, H E and Hau, J (2003) In In Vivo 17(1). p.1-4
Abstract
Fetal antigen 1 (FA1) is a circulating glycoprotein containing six epidermal growth factor (EGF)-like repeats. FA1's larger membrane-bound precursor is defined by the cDNAs referred to as either human delta-like (dlk) or human adrenal specific cDNA, pG2. In rodents FA1 has also been studied under the names of preadipocyte factor 1 (Pref-1), and zona glomerulosa-specific factor (ZOG). FA1 is abundantly expressed in fetal tissues, but in the mature cells of the adult organism the tissue presence of the protein seems to be restricted to neuroendocrine tissues. The present study demonstrates FA1 localisation in endocrine tissues of the adult female rat in which the protein was found present in the medulla and the zona glomerulosa of the cortex... (More)
Fetal antigen 1 (FA1) is a circulating glycoprotein containing six epidermal growth factor (EGF)-like repeats. FA1's larger membrane-bound precursor is defined by the cDNAs referred to as either human delta-like (dlk) or human adrenal specific cDNA, pG2. In rodents FA1 has also been studied under the names of preadipocyte factor 1 (Pref-1), and zona glomerulosa-specific factor (ZOG). FA1 is abundantly expressed in fetal tissues, but in the mature cells of the adult organism the tissue presence of the protein seems to be restricted to neuroendocrine tissues. The present study demonstrates FA1 localisation in endocrine tissues of the adult female rat in which the protein was found present in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells. No staining was found in the pancreas, which is in contrast to what has been described in the human. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
In Vivo
volume
17
issue
1
pages
1 - 4
publisher
In vivo
external identifiers
  • pmid:12655782
  • scopus:0037237513
ISSN
0258-851X
language
English
LU publication?
yes
id
52578519-933f-41ed-8692-a75f96aa8a14 (old id 1127409)
date added to LUP
2008-06-09 13:25:27
date last changed
2018-01-07 09:12:26
@article{52578519-933f-41ed-8692-a75f96aa8a14,
  abstract     = {Fetal antigen 1 (FA1) is a circulating glycoprotein containing six epidermal growth factor (EGF)-like repeats. FA1's larger membrane-bound precursor is defined by the cDNAs referred to as either human delta-like (dlk) or human adrenal specific cDNA, pG2. In rodents FA1 has also been studied under the names of preadipocyte factor 1 (Pref-1), and zona glomerulosa-specific factor (ZOG). FA1 is abundantly expressed in fetal tissues, but in the mature cells of the adult organism the tissue presence of the protein seems to be restricted to neuroendocrine tissues. The present study demonstrates FA1 localisation in endocrine tissues of the adult female rat in which the protein was found present in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells. No staining was found in the pancreas, which is in contrast to what has been described in the human.},
  author       = {Hedlund, G Persdotter and Carlsson, H E and Shieck, E and Nilsson, I and Lundblad, Cornelia and Arons, S and Iversen, A K and Looman, C and Jensen, H E and Hau, J},
  issn         = {0258-851X},
  language     = {eng},
  number       = {1},
  pages        = {1--4},
  publisher    = {In vivo},
  series       = {In Vivo},
  title        = {Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland},
  volume       = {17},
  year         = {2003},
}