Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
(2003) In American Journal of Physiology: Endocrinology and Metabolism 285(5). p.1047-1054- Abstract
- We investigated the functional impact of a recently described islet-specific loss of sympathetic nerves that occurs soon after the autoimmune destruction of beta-cells in the BB diabetic rat (35). We found that the portal venous (PV) glucagon response to sympathetic nerve stimulation (SNS) was markedly impaired in newly diabetic BB rats (BB D). We next found a normal glucagon response to intravenous epinephrine in BB D, eliminating the possibility of a generalized secretory defect of the BB D alpha-cell as the mediator of the impaired glucagon response to SNS. We then sought to determine whether the glucagon impairment to SNS in BB D was due solely to their loss of islet sympathetic nerve terminals or whether other effects of autoimmune... (More)
- We investigated the functional impact of a recently described islet-specific loss of sympathetic nerves that occurs soon after the autoimmune destruction of beta-cells in the BB diabetic rat (35). We found that the portal venous (PV) glucagon response to sympathetic nerve stimulation (SNS) was markedly impaired in newly diabetic BB rats (BB D). We next found a normal glucagon response to intravenous epinephrine in BB D, eliminating the possibility of a generalized secretory defect of the BB D alpha-cell as the mediator of the impaired glucagon response to SNS. We then sought to determine whether the glucagon impairment to SNS in BB D was due solely to their loss of islet sympathetic nerve terminals or whether other effects of autoimmune diabetes contributed. We therefore reproduced, in nondiabetic Wistar rats, an islet nerve terminal loss similar to that in BB D with systemic administration of the sympathetic neurotoxin 6-hydroxydopamine. The impairment of the glucagon response to SNS (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1127420
- author
- Mundinger, Thomas O ; Mei, Qi ; Figlewicz, Dianne P ; Lernmark, Åke LU and Taborsky, Gerald J Jr
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Physiology: Endocrinology and Metabolism
- volume
- 285
- issue
- 5
- pages
- 1047 - 1054
- publisher
- American Physiological Society
- external identifiers
-
- scopus:0142084666
- pmid:12876072
- ISSN
- 1522-1555
- DOI
- 10.1152/ajpendo.00136.2003
- language
- English
- LU publication?
- no
- id
- ac712d83-c892-4ccc-860e-e8040cb90c91 (old id 1127420)
- date added to LUP
- 2016-04-01 17:12:40
- date last changed
- 2022-04-23 03:30:56
@article{ac712d83-c892-4ccc-860e-e8040cb90c91, abstract = {{We investigated the functional impact of a recently described islet-specific loss of sympathetic nerves that occurs soon after the autoimmune destruction of beta-cells in the BB diabetic rat (35). We found that the portal venous (PV) glucagon response to sympathetic nerve stimulation (SNS) was markedly impaired in newly diabetic BB rats (BB D). We next found a normal glucagon response to intravenous epinephrine in BB D, eliminating the possibility of a generalized secretory defect of the BB D alpha-cell as the mediator of the impaired glucagon response to SNS. We then sought to determine whether the glucagon impairment to SNS in BB D was due solely to their loss of islet sympathetic nerve terminals or whether other effects of autoimmune diabetes contributed. We therefore reproduced, in nondiabetic Wistar rats, an islet nerve terminal loss similar to that in BB D with systemic administration of the sympathetic neurotoxin 6-hydroxydopamine. The impairment of the glucagon response to SNS}}, author = {{Mundinger, Thomas O and Mei, Qi and Figlewicz, Dianne P and Lernmark, Åke and Taborsky, Gerald J Jr}}, issn = {{1522-1555}}, language = {{eng}}, number = {{5}}, pages = {{1047--1054}}, publisher = {{American Physiological Society}}, series = {{American Journal of Physiology: Endocrinology and Metabolism}}, title = {{Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.}}, url = {{http://dx.doi.org/10.1152/ajpendo.00136.2003}}, doi = {{10.1152/ajpendo.00136.2003}}, volume = {{285}}, year = {{2003}}, }