Decreased angiogenic activity in breast cancer in ever-users of oral contraceptive therapy--preliminary report
(2003) In Anticancer research 23(3C). p.2875-2878- Abstract
- BACKGROUND: Angiogenic activity defined by microvessel density or measurement of vascular endothelial growth factor is a key process under physiological and malignant conditions in steroid hormone responding organs. The aim of this study was to relate microvessel density (MVD) in primary breast cancer to reproductive data and use of exogenous hormones. MATERIAL AND METHODS: MVD was calculated retrospectively in forty-two consecutive tumours and related to clinical, histopathological and gynecological data. RESULTS: Tumours in ever-users of oral contraceptive therapy (OC) had lower MVD (p = 0.002), a finding not explained by smaller tumour size or lower histological grade. There was no influence on MVD by other reproductive data.... (More)
- BACKGROUND: Angiogenic activity defined by microvessel density or measurement of vascular endothelial growth factor is a key process under physiological and malignant conditions in steroid hormone responding organs. The aim of this study was to relate microvessel density (MVD) in primary breast cancer to reproductive data and use of exogenous hormones. MATERIAL AND METHODS: MVD was calculated retrospectively in forty-two consecutive tumours and related to clinical, histopathological and gynecological data. RESULTS: Tumours in ever-users of oral contraceptive therapy (OC) had lower MVD (p = 0.002), a finding not explained by smaller tumour size or lower histological grade. There was no influence on MVD by other reproductive data. CONCLUSION: These preliminary data on a supposed interaction between the use of OC and angiogenesis in breast cancer indicate that biological properties in breast tumours may be altered by ever-use of OC, but have to be further explored in an extended number of patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1127586
- author
- Rydén, Lisa LU ; Boiesen, Poul and Jönsson, Per-Ebbe LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anticancer research
- volume
- 23
- issue
- 3C
- pages
- 2875 - 2878
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:12926126
- scopus:0042123568
- ISSN
- 1791-7530
- language
- English
- LU publication?
- yes
- id
- 06bfe394-4e3c-4619-b713-bf4af5eee20f (old id 1127586)
- date added to LUP
- 2016-04-01 12:08:09
- date last changed
- 2022-02-18 18:22:32
@article{06bfe394-4e3c-4619-b713-bf4af5eee20f, abstract = {{BACKGROUND: Angiogenic activity defined by microvessel density or measurement of vascular endothelial growth factor is a key process under physiological and malignant conditions in steroid hormone responding organs. The aim of this study was to relate microvessel density (MVD) in primary breast cancer to reproductive data and use of exogenous hormones. MATERIAL AND METHODS: MVD was calculated retrospectively in forty-two consecutive tumours and related to clinical, histopathological and gynecological data. RESULTS: Tumours in ever-users of oral contraceptive therapy (OC) had lower MVD (p = 0.002), a finding not explained by smaller tumour size or lower histological grade. There was no influence on MVD by other reproductive data. CONCLUSION: These preliminary data on a supposed interaction between the use of OC and angiogenesis in breast cancer indicate that biological properties in breast tumours may be altered by ever-use of OC, but have to be further explored in an extended number of patients.}}, author = {{Rydén, Lisa and Boiesen, Poul and Jönsson, Per-Ebbe}}, issn = {{1791-7530}}, language = {{eng}}, number = {{3C}}, pages = {{2875--2878}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{Decreased angiogenic activity in breast cancer in ever-users of oral contraceptive therapy--preliminary report}}, volume = {{23}}, year = {{2003}}, }