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Decreased angiogenic activity in breast cancer in ever-users of oral contraceptive therapy--preliminary report

Rydén, Lisa LU ; Boiesen, Poul and Jönsson, Per-Ebbe LU (2003) In Anticancer research 23(3C). p.2875-2878
Abstract
BACKGROUND: Angiogenic activity defined by microvessel density or measurement of vascular endothelial growth factor is a key process under physiological and malignant conditions in steroid hormone responding organs. The aim of this study was to relate microvessel density (MVD) in primary breast cancer to reproductive data and use of exogenous hormones. MATERIAL AND METHODS: MVD was calculated retrospectively in forty-two consecutive tumours and related to clinical, histopathological and gynecological data. RESULTS: Tumours in ever-users of oral contraceptive therapy (OC) had lower MVD (p = 0.002), a finding not explained by smaller tumour size or lower histological grade. There was no influence on MVD by other reproductive data.... (More)
BACKGROUND: Angiogenic activity defined by microvessel density or measurement of vascular endothelial growth factor is a key process under physiological and malignant conditions in steroid hormone responding organs. The aim of this study was to relate microvessel density (MVD) in primary breast cancer to reproductive data and use of exogenous hormones. MATERIAL AND METHODS: MVD was calculated retrospectively in forty-two consecutive tumours and related to clinical, histopathological and gynecological data. RESULTS: Tumours in ever-users of oral contraceptive therapy (OC) had lower MVD (p = 0.002), a finding not explained by smaller tumour size or lower histological grade. There was no influence on MVD by other reproductive data. CONCLUSION: These preliminary data on a supposed interaction between the use of OC and angiogenesis in breast cancer indicate that biological properties in breast tumours may be altered by ever-use of OC, but have to be further explored in an extended number of patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer research
volume
23
issue
3C
pages
2875 - 2878
publisher
International Institute of Cancer Research
external identifiers
  • pmid:12926126
  • scopus:0042123568
ISSN
1791-7530
language
English
LU publication?
yes
id
06bfe394-4e3c-4619-b713-bf4af5eee20f (old id 1127586)
date added to LUP
2008-06-05 13:45:33
date last changed
2018-10-03 10:12:14
@article{06bfe394-4e3c-4619-b713-bf4af5eee20f,
  abstract     = {BACKGROUND: Angiogenic activity defined by microvessel density or measurement of vascular endothelial growth factor is a key process under physiological and malignant conditions in steroid hormone responding organs. The aim of this study was to relate microvessel density (MVD) in primary breast cancer to reproductive data and use of exogenous hormones. MATERIAL AND METHODS: MVD was calculated retrospectively in forty-two consecutive tumours and related to clinical, histopathological and gynecological data. RESULTS: Tumours in ever-users of oral contraceptive therapy (OC) had lower MVD (p = 0.002), a finding not explained by smaller tumour size or lower histological grade. There was no influence on MVD by other reproductive data. CONCLUSION: These preliminary data on a supposed interaction between the use of OC and angiogenesis in breast cancer indicate that biological properties in breast tumours may be altered by ever-use of OC, but have to be further explored in an extended number of patients.},
  author       = {Rydén, Lisa and Boiesen, Poul and Jönsson, Per-Ebbe},
  issn         = {1791-7530},
  language     = {eng},
  number       = {3C},
  pages        = {2875--2878},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer research},
  title        = {Decreased angiogenic activity in breast cancer in ever-users of oral contraceptive therapy--preliminary report},
  volume       = {23},
  year         = {2003},
}