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Heparan sulfate proteoglycan as a plasma membrane carrier

Belting, Mattias LU (2003) In Trends in Biochemical Sciences 28(3). p.145-151
Abstract
The plasma membrane defines the border of living cells and provides a barrier to extracellular components. Advances in molecular biology have resulted in the development of novel therapeutic strategies (e.g. gene therapy and cellular protein delivery) which rely on the entry of charged macromolecules into the intracellular compartment. Recent reports demonstrate an intriguing role for heparan sulfate proteoglycans in cellular internalization of viruses, basic peptides and polycation-nucleic-acid complexes and the possibility that they have important implications for gene transfer and protein delivery to mammalian cells. This review focuses on heparan sulfate proteoglycan as a plasma membrane carrier.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Biochemical Sciences
volume
28
issue
3
pages
145 - 151
publisher
Elsevier
external identifiers
  • pmid:12633994
  • scopus:0037333830
ISSN
0167-7640
DOI
10.1016/S0968-0004(03)00031-8
language
English
LU publication?
yes
id
a7bfd267-cd28-4eec-8bd8-e1f31b38f800 (old id 1127610)
date added to LUP
2008-06-02 12:00:31
date last changed
2018-01-07 05:52:31
@article{a7bfd267-cd28-4eec-8bd8-e1f31b38f800,
  abstract     = {The plasma membrane defines the border of living cells and provides a barrier to extracellular components. Advances in molecular biology have resulted in the development of novel therapeutic strategies (e.g. gene therapy and cellular protein delivery) which rely on the entry of charged macromolecules into the intracellular compartment. Recent reports demonstrate an intriguing role for heparan sulfate proteoglycans in cellular internalization of viruses, basic peptides and polycation-nucleic-acid complexes and the possibility that they have important implications for gene transfer and protein delivery to mammalian cells. This review focuses on heparan sulfate proteoglycan as a plasma membrane carrier.},
  author       = {Belting, Mattias},
  issn         = {0167-7640},
  language     = {eng},
  number       = {3},
  pages        = {145--151},
  publisher    = {Elsevier},
  series       = {Trends in Biochemical Sciences},
  title        = {Heparan sulfate proteoglycan as a plasma membrane carrier},
  url          = {http://dx.doi.org/10.1016/S0968-0004(03)00031-8},
  volume       = {28},
  year         = {2003},
}