Advanced

Genetic amniocentesis:a risk factor for preterm delivery?

Medda, Emanuela; Donati, Serena; Spinelli, Angela; Di Renzo, Gian Carlo; Czech Republic, Finland, France, Germany, Greece, Italy, The Netherlands, Slovak Republic, Spain and Sweden:, EUROPOP Group; Marsal, Karel LU and al, et (2003) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 110(2). p.153-158
Abstract
Objective: To determine whether genetic amniocentesis performed in the second trimester of pregnancy is associated with the risk of preterm delivery. Study design: Case–control study performed in several departments of obstetrics and gynaecology of nine European countries. Three thousand and ninety-one preterm births and 5298 controls randomly selected from singleton births born at term during 1994–1997 were analysed. Logistic regression models were used to compare preterm births altogether and, separately, spontaneous preterm delivery and induced preterm delivery. Results: An increased risk of preterm delivery was found in women having second trimester genetic amniocentesis after taking account of other risk factors and confounding... (More)
Objective: To determine whether genetic amniocentesis performed in the second trimester of pregnancy is associated with the risk of preterm delivery. Study design: Case–control study performed in several departments of obstetrics and gynaecology of nine European countries. Three thousand and ninety-one preterm births and 5298 controls randomly selected from singleton births born at term during 1994–1997 were analysed. Logistic regression models were used to compare preterm births altogether and, separately, spontaneous preterm delivery and induced preterm delivery. Results: An increased risk of preterm delivery was found in women having second trimester genetic amniocentesis after taking account of other risk factors and confounding variables (odds ratios (OR)=1.59, 95% confidence intervals (95% CI): 1.31–1.92). The association was statistically significant and similar for spontaneous preterm delivery and induced preterm delivery. Conclusion: The study shows an association between preterm delivery and genetic amniocentesis. In view of the wide use of amniocentesis, further research on the etiologic role of this prenatal diagnostic technique is needed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Second trimester genetic amniocentesis, Preterm delivery, Europe
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
110
issue
2
pages
153 - 158
publisher
Elsevier
external identifiers
  • scopus:0042326739
ISSN
0301-2115
DOI
language
English
LU publication?
yes
id
c8fc3a7f-16f1-4112-b43a-9b995c375cf4 (old id 1127891)
date added to LUP
2008-08-26 14:35:41
date last changed
2018-05-29 09:26:20
@article{c8fc3a7f-16f1-4112-b43a-9b995c375cf4,
  abstract     = {Objective: To determine whether genetic amniocentesis performed in the second trimester of pregnancy is associated with the risk of preterm delivery. Study design: Case–control study performed in several departments of obstetrics and gynaecology of nine European countries. Three thousand and ninety-one preterm births and 5298 controls randomly selected from singleton births born at term during 1994–1997 were analysed. Logistic regression models were used to compare preterm births altogether and, separately, spontaneous preterm delivery and induced preterm delivery. Results: An increased risk of preterm delivery was found in women having second trimester genetic amniocentesis after taking account of other risk factors and confounding variables (odds ratios (OR)=1.59, 95% confidence intervals (95% CI): 1.31–1.92). The association was statistically significant and similar for spontaneous preterm delivery and induced preterm delivery. Conclusion: The study shows an association between preterm delivery and genetic amniocentesis. In view of the wide use of amniocentesis, further research on the etiologic role of this prenatal diagnostic technique is needed.},
  author       = {Medda, Emanuela and Donati, Serena and Spinelli, Angela and Di Renzo, Gian Carlo and Czech Republic, Finland, France, Germany, Greece, Italy, The Netherlands, Slovak Republic, Spain and Sweden:, EUROPOP Group and Marsal, Karel and al, et},
  issn         = {0301-2115},
  keyword      = {Second trimester genetic amniocentesis,Preterm delivery,Europe},
  language     = {eng},
  number       = {2},
  pages        = {153--158},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Genetic amniocentesis:a risk factor for preterm delivery?},
  url          = {http://dx.doi.org/},
  volume       = {110},
  year         = {2003},
}