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Macrophages in inflammatory bowel disease

Grip, Olof; Janciauskiene, Sabina and Lindgren, Stefan LU (2003) In Current Drug Targets. Inflammation & Allergy 2(2). p.155-160
Abstract
Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel... (More)
Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel therapies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Drug Targets. Inflammation & Allergy
volume
2
issue
2
pages
155 - 160
publisher
Bentham Science Publishers
external identifiers
  • pmid:14561168
  • scopus:0642314139
ISSN
1568-010X
language
English
LU publication?
yes
id
731f7d30-c558-44be-a1fa-b5f22c71bc34 (old id 1128073)
date added to LUP
2008-06-04 11:04:17
date last changed
2018-10-14 04:01:54
@article{731f7d30-c558-44be-a1fa-b5f22c71bc34,
  abstract     = {Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel therapies.},
  author       = {Grip, Olof and Janciauskiene, Sabina and Lindgren, Stefan},
  issn         = {1568-010X},
  language     = {eng},
  number       = {2},
  pages        = {155--160},
  publisher    = {Bentham Science Publishers},
  series       = {Current Drug Targets. Inflammation & Allergy},
  title        = {Macrophages in inflammatory bowel disease},
  volume       = {2},
  year         = {2003},
}