Macrophages in inflammatory bowel disease
(2003) In Current Drug Targets. Inflammation & Allergy 2(2). p.155-160- Abstract
- Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel... (More)
- Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel therapies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1128073
- author
- Grip, Olof ; Janciauskiene, Sabina and Lindgren, Stefan LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Drug Targets. Inflammation & Allergy
- volume
- 2
- issue
- 2
- pages
- 155 - 160
- publisher
- Bentham Science Publishers
- external identifiers
-
- pmid:14561168
- scopus:0642314139
- ISSN
- 1568-010X
- language
- English
- LU publication?
- yes
- id
- 731f7d30-c558-44be-a1fa-b5f22c71bc34 (old id 1128073)
- date added to LUP
- 2016-04-01 15:17:03
- date last changed
- 2022-01-28 04:37:37
@article{731f7d30-c558-44be-a1fa-b5f22c71bc34,
abstract = {{Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel therapies.}},
author = {{Grip, Olof and Janciauskiene, Sabina and Lindgren, Stefan}},
issn = {{1568-010X}},
language = {{eng}},
number = {{2}},
pages = {{155--160}},
publisher = {{Bentham Science Publishers}},
series = {{Current Drug Targets. Inflammation & Allergy}},
title = {{Macrophages in inflammatory bowel disease}},
volume = {{2}},
year = {{2003}},
}