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Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease

Newman, C J; Laurini, Ricardo LU ; Lesbros, Y; Reinberg, O and Meyrat, B J (2003) In Pediatric Surgery International 19(9-10). p.662-668
Abstract
Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's... (More)
Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung's disease (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Surgery International
volume
19
issue
9-10
pages
662 - 668
publisher
Springer
external identifiers
  • pmid:14566416
  • scopus:0345863392
ISSN
1437-9813
DOI
10.1007/s00383-003-1026-1
language
English
LU publication?
yes
id
140b520b-f725-4267-a3e3-d2ab20da7839 (old id 1128188)
date added to LUP
2008-06-02 15:46:37
date last changed
2018-05-29 10:57:00
@article{140b520b-f725-4267-a3e3-d2ab20da7839,
  abstract     = {Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung's disease},
  author       = {Newman, C J and Laurini, Ricardo and Lesbros, Y and Reinberg, O and Meyrat, B J},
  issn         = {1437-9813},
  language     = {eng},
  number       = {9-10},
  pages        = {662--668},
  publisher    = {Springer},
  series       = {Pediatric Surgery International},
  title        = {Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease},
  url          = {http://dx.doi.org/10.1007/s00383-003-1026-1},
  volume       = {19},
  year         = {2003},
}