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Effects of vacuum-assisted closure on central hemodynamics in a sternotomy wound model

Sjögren, Johan LU ; Gustafsson, Ronny LU ; Wackenfors, Angelica LU ; Malmsjö, Malin LU ; Algotsson, Lars LU and Ingemansson, Richard LU (2004) In Interactive Cardiovascular and Thoracic Surgery 3(4). p.666-671
Abstract
Several authors have reported promising results with vacuum-assisted closure therapy in poststernotomy mediastinitis. The aim of this study was to investigate the hemodynamic outcome following the application of six negative pressures on an open sternotomy wound. Six 70-kg pigs underwent median sternotomy followed by vacuum-assisted closure therapy. Six negative pressures (-50, -75, -100, -125, -150, and -175mmHg) were applied to each pig for 30min each while hemodynamic parameters were measured. An increase in cardiac output was observed at -75mmHg when compared to the other five pressures: -50mmHg (P<0.05; CI 0.12-1.13l/min), -100mmHg (P<0.001; CI 0.34-1.32l/min), -125mmHg (P<0.001; CI 0.51-1.52l/min), -150mmHg (P<0.001; CI... (More)
Several authors have reported promising results with vacuum-assisted closure therapy in poststernotomy mediastinitis. The aim of this study was to investigate the hemodynamic outcome following the application of six negative pressures on an open sternotomy wound. Six 70-kg pigs underwent median sternotomy followed by vacuum-assisted closure therapy. Six negative pressures (-50, -75, -100, -125, -150, and -175mmHg) were applied to each pig for 30min each while hemodynamic parameters were measured. An increase in cardiac output was observed at -75mmHg when compared to the other five pressures: -50mmHg (P<0.05; CI 0.12-1.13l/min), -100mmHg (P<0.001; CI 0.34-1.32l/min), -125mmHg (P<0.001; CI 0.51-1.52l/min), -150mmHg (P<0.001; CI 0.50-1.47l/min), and -175mmHg (P<0.05; CI 0.13-1.17l/min). A decrease in systemic vascular resistance was observed at -75mmHg when compared to -125mmHg (P<0.01; CI 108-552dyn.s/cm(5)) and -150mmHg (P<0.01; CI 90-543dyn.s/cm(5)), but not compared to the other pressures. No change (P=ns) was observed in heart frequency, mean arterial pressure or central venous pressure. Our data demonstrates that vacuum-assisted closure therapy of -50 to -175mmHg does not impair the central hemodynamics in a porcine sternotomy model. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Interactive Cardiovascular and Thoracic Surgery
volume
3
issue
4
pages
666 - 671
publisher
European Association of Cardio-Thoracic Surgery
external identifiers
  • pmid:17670336
  • scopus:9644279706
ISSN
1569-9285
DOI
10.1016/j.icvts.2004.08.003
language
English
LU publication?
yes
id
6eeef015-910f-45fd-8bc4-875c08424d71 (old id 1128992)
date added to LUP
2008-06-18 12:00:00
date last changed
2017-05-28 03:39:04
@article{6eeef015-910f-45fd-8bc4-875c08424d71,
  abstract     = {Several authors have reported promising results with vacuum-assisted closure therapy in poststernotomy mediastinitis. The aim of this study was to investigate the hemodynamic outcome following the application of six negative pressures on an open sternotomy wound. Six 70-kg pigs underwent median sternotomy followed by vacuum-assisted closure therapy. Six negative pressures (-50, -75, -100, -125, -150, and -175mmHg) were applied to each pig for 30min each while hemodynamic parameters were measured. An increase in cardiac output was observed at -75mmHg when compared to the other five pressures: -50mmHg (P&lt;0.05; CI 0.12-1.13l/min), -100mmHg (P&lt;0.001; CI 0.34-1.32l/min), -125mmHg (P&lt;0.001; CI 0.51-1.52l/min), -150mmHg (P&lt;0.001; CI 0.50-1.47l/min), and -175mmHg (P&lt;0.05; CI 0.13-1.17l/min). A decrease in systemic vascular resistance was observed at -75mmHg when compared to -125mmHg (P&lt;0.01; CI 108-552dyn.s/cm(5)) and -150mmHg (P&lt;0.01; CI 90-543dyn.s/cm(5)), but not compared to the other pressures. No change (P=ns) was observed in heart frequency, mean arterial pressure or central venous pressure. Our data demonstrates that vacuum-assisted closure therapy of -50 to -175mmHg does not impair the central hemodynamics in a porcine sternotomy model.},
  author       = {Sjögren, Johan and Gustafsson, Ronny and Wackenfors, Angelica and Malmsjö, Malin and Algotsson, Lars and Ingemansson, Richard},
  issn         = {1569-9285},
  language     = {eng},
  number       = {4},
  pages        = {666--671},
  publisher    = {European Association of Cardio-Thoracic Surgery},
  series       = {Interactive Cardiovascular and Thoracic Surgery},
  title        = {Effects of vacuum-assisted closure on central hemodynamics in a sternotomy wound model},
  url          = {http://dx.doi.org/10.1016/j.icvts.2004.08.003},
  volume       = {3},
  year         = {2004},
}