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Reverse pharmacology and the de-orphanization of 7TM receptors

Kotarsky, Knut LU and Nilsson, Niclas E (2004) In Drug Discovery Today: Technologies 2(1). p.99-104
Abstract
Approximately 800 genes coding for seven-transmembrane, G-protein-coupled receptors have so far been recognized. In spite of this, many of these receptors are defined by their sequence only, and are therefore classified as orphan receptors. Without knowing what their endogenous ligands are, we lack the information needed to understand their physiological role and hence cannot make use of them as drug targets. In this communication, we discuss different strategies, as well as difficulties in the deorphanizing process.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Discovery Today: Technologies
volume
2
issue
1
pages
99 - 104
publisher
Elsevier
external identifiers
  • scopus:13244253657
ISSN
1740-6749
DOI
10.1016/j.ddtec.2004.07.003
language
English
LU publication?
yes
id
c5941581-3f1d-42f2-ba4a-2e153b5f921c (old id 1129094)
date added to LUP
2008-06-16 13:37:21
date last changed
2017-01-01 06:41:03
@article{c5941581-3f1d-42f2-ba4a-2e153b5f921c,
  abstract     = {Approximately 800 genes coding for seven-transmembrane, G-protein-coupled receptors have so far been recognized. In spite of this, many of these receptors are defined by their sequence only, and are therefore classified as orphan receptors. Without knowing what their endogenous ligands are, we lack the information needed to understand their physiological role and hence cannot make use of them as drug targets. In this communication, we discuss different strategies, as well as difficulties in the deorphanizing process.},
  author       = {Kotarsky, Knut and Nilsson, Niclas E},
  issn         = {1740-6749},
  language     = {eng},
  number       = {1},
  pages        = {99--104},
  publisher    = {Elsevier},
  series       = {Drug Discovery Today: Technologies},
  title        = {Reverse pharmacology and the de-orphanization of 7TM receptors},
  url          = {http://dx.doi.org/10.1016/j.ddtec.2004.07.003},
  volume       = {2},
  year         = {2004},
}