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Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

Shariatmadar, S ; Storry, Jill LU ; Sausais, L and Reid, M E (2004) In Immunohematology 20(1). p.63-66
Abstract
Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immunemediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient's DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4,096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunohematology
volume
20
issue
1
pages
63 - 66
publisher
American Red Cross
external identifiers
  • pmid:15373671
  • scopus:1442324864
ISSN
0894-203X
language
English
LU publication?
yes
id
348865a2-e7a2-40af-bf14-22b044230691 (old id 1129232)
date added to LUP
2016-04-01 17:12:08
date last changed
2022-01-29 01:06:17
@article{348865a2-e7a2-40af-bf14-22b044230691,
  abstract     = {{Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immunemediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient's DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4,096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.}},
  author       = {{Shariatmadar, S and Storry, Jill and Sausais, L and Reid, M E}},
  issn         = {{0894-203X}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{63--66}},
  publisher    = {{American Red Cross}},
  series       = {{Immunohematology}},
  title        = {{Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery}},
  volume       = {{20}},
  year         = {{2004}},
}