Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery
(2004) In Immunohematology 20(1). p.63-66- Abstract
- Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immunemediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient's DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4,096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1129232
- author
- Shariatmadar, S ; Storry, Jill LU ; Sausais, L and Reid, M E
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunohematology
- volume
- 20
- issue
- 1
- pages
- 63 - 66
- publisher
- American Red Cross
- external identifiers
-
- pmid:15373671
- scopus:1442324864
- ISSN
- 0894-203X
- language
- English
- LU publication?
- yes
- id
- 348865a2-e7a2-40af-bf14-22b044230691 (old id 1129232)
- date added to LUP
- 2016-04-01 17:12:08
- date last changed
- 2022-01-29 01:06:17
@article{348865a2-e7a2-40af-bf14-22b044230691, abstract = {{Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immunemediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient's DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4,096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.}}, author = {{Shariatmadar, S and Storry, Jill and Sausais, L and Reid, M E}}, issn = {{0894-203X}}, language = {{eng}}, number = {{1}}, pages = {{63--66}}, publisher = {{American Red Cross}}, series = {{Immunohematology}}, title = {{Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery}}, volume = {{20}}, year = {{2004}}, }