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Vaccination for atherosclerosis: a novel therapeutic paradigm

Shah, Prediman K; Chyu, Kuang-Yuh; Fredrikson, Gunilla N and Nilsson, Jan LU (2004) In Expert Review of Vaccines 3(6). p.711-716
Abstract
Numerous studies have identified a role for the innate and adaptive immune response in atherosclerosis; both pro- and antiatherogenic roles for the immune responses have been demonstrated. Common autoantigens against which an immune response has been identified in experimental and human models of atherosclerosis include oxidized low-density lipopoteins, beta2 glycoprotein 1 and heat shock protein 60. Activation of atheroprotective adaptive immune responses have been demonstrated for oxidized low-density lipoprotein-related antigens. Conversely, atheroprotection has been demonstrated with the induction of immune tolerance through activation of mucosal immunity to heat shock protein 65/60 and beta2 glycoprotein 1. Recent identification of... (More)
Numerous studies have identified a role for the innate and adaptive immune response in atherosclerosis; both pro- and antiatherogenic roles for the immune responses have been demonstrated. Common autoantigens against which an immune response has been identified in experimental and human models of atherosclerosis include oxidized low-density lipopoteins, beta2 glycoprotein 1 and heat shock protein 60. Activation of atheroprotective adaptive immune responses have been demonstrated for oxidized low-density lipoprotein-related antigens. Conversely, atheroprotection has been demonstrated with the induction of immune tolerance through activation of mucosal immunity to heat shock protein 65/60 and beta2 glycoprotein 1. Recent identification of specific immunoreactive antigenic epitopes in the apolipoprotein B-100 component of low density lipoproetin and early experimental observations have provided proof of concept that active vaccination using specific apolipoprotein B-100-related antigens may emerge as a novel immunomodulating atheroprotective strategy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Expert Review of Vaccines
volume
3
issue
6
pages
711 - 716
publisher
Future Drugs Ltd
external identifiers
  • pmid:15606356
  • scopus:9644302510
ISSN
1744-8395
DOI
10.1586/14760584.3.6.711
language
English
LU publication?
yes
id
42b0377b-b197-4200-9572-74d51e282531 (old id 1129558)
date added to LUP
2008-06-17 16:08:37
date last changed
2017-01-01 04:30:27
@article{42b0377b-b197-4200-9572-74d51e282531,
  abstract     = {Numerous studies have identified a role for the innate and adaptive immune response in atherosclerosis; both pro- and antiatherogenic roles for the immune responses have been demonstrated. Common autoantigens against which an immune response has been identified in experimental and human models of atherosclerosis include oxidized low-density lipopoteins, beta2 glycoprotein 1 and heat shock protein 60. Activation of atheroprotective adaptive immune responses have been demonstrated for oxidized low-density lipoprotein-related antigens. Conversely, atheroprotection has been demonstrated with the induction of immune tolerance through activation of mucosal immunity to heat shock protein 65/60 and beta2 glycoprotein 1. Recent identification of specific immunoreactive antigenic epitopes in the apolipoprotein B-100 component of low density lipoproetin and early experimental observations have provided proof of concept that active vaccination using specific apolipoprotein B-100-related antigens may emerge as a novel immunomodulating atheroprotective strategy.},
  author       = {Shah, Prediman K and Chyu, Kuang-Yuh and Fredrikson, Gunilla N and Nilsson, Jan},
  issn         = {1744-8395},
  language     = {eng},
  number       = {6},
  pages        = {711--716},
  publisher    = {Future Drugs Ltd},
  series       = {Expert Review of Vaccines},
  title        = {Vaccination for atherosclerosis: a novel therapeutic paradigm},
  url          = {http://dx.doi.org/10.1586/14760584.3.6.711},
  volume       = {3},
  year         = {2004},
}