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Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.

Sommandas, Vinod; Rutledge, Elizabeth A.; Van Yserloo, Brian; Fuller, Jessica; Lernmark, Åke LU and Drexhage, Hemmo A. (2004) In Journal of Autoimmunity 25(1). p.1-12
Abstract
BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor... (More)
BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor apoptosis, a low MHC class II expression, a reduced IL-10 production and a reduced T cell stimulatory capacity of DC. From our previous report on DC differentiation defects in BB rats (only differing in iddm2) and the present report, we deduce that the abnorma (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BB rat, Diabetes, Dendritic cells, lyp gene
in
Journal of Autoimmunity
volume
25
issue
1
pages
1 - 12
publisher
Elsevier
external identifiers
  • scopus:22444444425
ISSN
0896-8411
DOI
10.1016/j.jaut.2005.05.002
language
English
LU publication?
no
id
ce2a493c-5209-4e01-ae0a-05f8f6415bb9 (old id 1129980)
date added to LUP
2008-06-18 13:26:47
date last changed
2017-01-01 05:17:18
@article{ce2a493c-5209-4e01-ae0a-05f8f6415bb9,
  abstract     = {BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor apoptosis, a low MHC class II expression, a reduced IL-10 production and a reduced T cell stimulatory capacity of DC. From our previous report on DC differentiation defects in BB rats (only differing in iddm2) and the present report, we deduce that the abnorma},
  author       = {Sommandas, Vinod and Rutledge, Elizabeth A. and Van Yserloo, Brian and Fuller, Jessica and Lernmark, Åke and Drexhage, Hemmo A.},
  issn         = {0896-8411},
  keyword      = {BB rat,Diabetes,Dendritic cells,lyp gene},
  language     = {eng},
  number       = {1},
  pages        = {1--12},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.},
  url          = {http://dx.doi.org/10.1016/j.jaut.2005.05.002},
  volume       = {25},
  year         = {2004},
}