Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.
(2004) In Journal of Immunology 173(11). p.6993-7002- Abstract
- Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and... (More)
- Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and Wistar-Furth (WF) rats. The eosinophil-recruiting chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated >5-fold in d65 DRlyp/lyp vs d65 DR+/+ pancreatic lymph nodes by microarray (p < 0.05) and quantitative RT-PCR stud (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1129984
- author
- Hessner, Martin J ; Wang, Xujing ; Meyer, Lisa ; Geoffrey, Rhonda ; Jia, Shuang ; Fuller, Jessica ; Lernmark, Åke LU and Ghosh, Soumitra
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunology
- volume
- 173
- issue
- 11
- pages
- 6993 - 7002
- publisher
- American Association of Immunologists
- external identifiers
-
- scopus:9144238154
- ISSN
- 1550-6606
- language
- English
- LU publication?
- no
- id
- 7c2a6d7f-2720-4459-815b-567ab701641d (old id 1129984)
- date added to LUP
- 2016-04-01 15:18:48
- date last changed
- 2022-02-12 07:22:39
@article{7c2a6d7f-2720-4459-815b-567ab701641d, abstract = {{Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and Wistar-Furth (WF) rats. The eosinophil-recruiting chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated >5-fold in d65 DRlyp/lyp vs d65 DR+/+ pancreatic lymph nodes by microarray (p < 0.05) and quantitative RT-PCR stud}}, author = {{Hessner, Martin J and Wang, Xujing and Meyer, Lisa and Geoffrey, Rhonda and Jia, Shuang and Fuller, Jessica and Lernmark, Åke and Ghosh, Soumitra}}, issn = {{1550-6606}}, language = {{eng}}, number = {{11}}, pages = {{6993--7002}}, publisher = {{American Association of Immunologists}}, series = {{Journal of Immunology}}, title = {{Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.}}, volume = {{173}}, year = {{2004}}, }