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Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.

Hessner, Martin J; Wang, Xujing; Meyer, Lisa; Geoffrey, Rhonda; Jia, Shuang; Fuller, Jessica; Lernmark, Åke LU and Ghosh, Soumitra (2004) In Journal of Immunology 173(11). p.6993-7002
Abstract
Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and... (More)
Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and Wistar-Furth (WF) rats. The eosinophil-recruiting chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated >5-fold in d65 DRlyp/lyp vs d65 DR+/+ pancreatic lymph nodes by microarray (p < 0.05) and quantitative RT-PCR stud (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
173
issue
11
pages
6993 - 7002
publisher
American Association of Immunologists
external identifiers
  • scopus:9144238154
ISSN
1550-6606
language
English
LU publication?
no
id
7c2a6d7f-2720-4459-815b-567ab701641d (old id 1129984)
date added to LUP
2008-06-16 09:52:51
date last changed
2017-06-04 04:14:39
@article{7c2a6d7f-2720-4459-815b-567ab701641d,
  abstract     = {Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+/+ rat does not. To better understand immune processes during development of T1DM, gene expression profiling at day (d) 40 (before insulitis) and d65 (before disease onset) was conducted on pancreatic lymph nodes of DRlyp/lyp, DR+/+, and Wistar-Furth (WF) rats. The eosinophil-recruiting chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated &gt;5-fold in d65 DRlyp/lyp vs d65 DR+/+ pancreatic lymph nodes by microarray (p &lt; 0.05) and quantitative RT-PCR stud},
  author       = {Hessner, Martin J and Wang, Xujing and Meyer, Lisa and Geoffrey, Rhonda and Jia, Shuang and Fuller, Jessica and Lernmark, Åke and Ghosh, Soumitra},
  issn         = {1550-6606},
  language     = {eng},
  number       = {11},
  pages        = {6993--7002},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.},
  volume       = {173},
  year         = {2004},
}