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A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.

Padmos, Roos C; Bekris, Lynn; Knijff, Esther M; Tiemeier, Henning; Kupka, Ralph W; Cohen, Dan; Nolen, Willem A; Lernmark, Åke LU and Drexhage, Hemmo A (2004) In Biological Psychiatry 56(7). p.476-482
Abstract
BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. RESULTS: The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared... (More)
BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. RESULTS: The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared with those in healthy control subjects (11.7 vs. 6.1% and 11.3 vs. 2.6% respectively; p <.05). Schizophrenia patients did not show such statistically higher prevalence. The elevated prevalence of ATPA and GAD65A in bipolar disorder was associated with n (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Biological Psychiatry
volume
56
issue
7
pages
476 - 482
publisher
Society of Biological Psychiatry Published by Elsevier Inc.
external identifiers
  • scopus:4644250607
ISSN
0006-3223
DOI
10.1016/j.biopsych.2004.07.003
language
English
LU publication?
no
id
fb6d3944-1fd8-403d-8a6a-3740e8002861 (old id 1129991)
date added to LUP
2008-06-18 08:47:57
date last changed
2017-11-05 03:34:15
@article{fb6d3944-1fd8-403d-8a6a-3740e8002861,
  abstract     = {BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. RESULTS: The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared with those in healthy control subjects (11.7 vs. 6.1% and 11.3 vs. 2.6% respectively; p &lt;.05). Schizophrenia patients did not show such statistically higher prevalence. The elevated prevalence of ATPA and GAD65A in bipolar disorder was associated with n},
  author       = {Padmos, Roos C and Bekris, Lynn and Knijff, Esther M and Tiemeier, Henning and Kupka, Ralph W and Cohen, Dan and Nolen, Willem A and Lernmark, Åke and Drexhage, Hemmo A},
  issn         = {0006-3223},
  language     = {eng},
  number       = {7},
  pages        = {476--482},
  publisher    = {Society of Biological Psychiatry Published by Elsevier Inc.},
  series       = {Biological Psychiatry},
  title        = {A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.},
  url          = {http://dx.doi.org/10.1016/j.biopsych.2004.07.003},
  volume       = {56},
  year         = {2004},
}