Progression from normal breast pathology to breast cancer is associated with increasing prevalence of mouse mammary tumor virus-like sequences in men and women
(2004) In Cancer Research 64(14). p.4755-4759- Abstract
- Mouse mammary tumor virus (MMTV)-like sequences have been found in up to 40% of breast cancer samples but in <2% of normal breast tissue samples from Australian women studied by our group. Screening of a larger and more diverse cohort of female breast cancer samples has now shown a correlation of MMTV-like sequences with the severity (grade) of breast cancer. Thirty-two percent (43 of 136) of female breast cancer samples were positive for MMTV-like sequences when screened using PCR. A significant gradient of MMTV positivity was observed with increasing severity of cancer from 23% of infiltrating ductal carcinoma (IDC) grade I tumors to 34% of IDC grade II tumors (P = 0.00034) and 38% of IDC grade III tumors (P = 0.00002). We also report... (More)
- Mouse mammary tumor virus (MMTV)-like sequences have been found in up to 40% of breast cancer samples but in <2% of normal breast tissue samples from Australian women studied by our group. Screening of a larger and more diverse cohort of female breast cancer samples has now shown a correlation of MMTV-like sequences with the severity (grade) of breast cancer. Thirty-two percent (43 of 136) of female breast cancer samples were positive for MMTV-like sequences when screened using PCR. A significant gradient of MMTV positivity was observed with increasing severity of cancer from 23% of infiltrating ductal carcinoma (IDC) grade I tumors to 34% of IDC grade II tumors (P = 0.00034) and 38% of IDC grade III tumors (P = 0.00002). We also report for the first time the detection of MMTV-like sequences in 62% (8 of 13) of male breast cancer samples and 19% (10 of 52) of male gynecomastia samples screened. MMTV-like sequences were demonstrated in various premalignant breast lesions of females, including fibroadenoma (20%) and fibrocystic disease (28%) samples, at a significantly higher prevalence than that seen in normal breast tissue (1.8%; P = 0.00001). Study of a longitudinal cohort of female breast cancer patients indicated that MMTV was co-incident with tumor but was not present when tumor was absent on histology. These results support the association of MMTV-like sequences with development of breast tumors in men and women and suggest association of MMTV with increasing severity of cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1130013
- author
- Ford, Caroline LU ; Faedo, Margaret ; Crouch, Roger ; Lawson, James S and Rawlinson, William D
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Research
- volume
- 64
- issue
- 14
- pages
- 4755 - 4759
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- pmid:15256443
- scopus:3142783520
- pmid:15256443
- ISSN
- 1538-7445
- DOI
- 10.1158/0008-5472.CAN-03-3804
- language
- English
- LU publication?
- yes
- id
- 9194841a-a96e-4fbf-a2b6-82f7c0786f7e (old id 1130013)
- date added to LUP
- 2016-04-01 16:02:26
- date last changed
- 2022-01-28 08:49:52
@article{9194841a-a96e-4fbf-a2b6-82f7c0786f7e, abstract = {{Mouse mammary tumor virus (MMTV)-like sequences have been found in up to 40% of breast cancer samples but in <2% of normal breast tissue samples from Australian women studied by our group. Screening of a larger and more diverse cohort of female breast cancer samples has now shown a correlation of MMTV-like sequences with the severity (grade) of breast cancer. Thirty-two percent (43 of 136) of female breast cancer samples were positive for MMTV-like sequences when screened using PCR. A significant gradient of MMTV positivity was observed with increasing severity of cancer from 23% of infiltrating ductal carcinoma (IDC) grade I tumors to 34% of IDC grade II tumors (P = 0.00034) and 38% of IDC grade III tumors (P = 0.00002). We also report for the first time the detection of MMTV-like sequences in 62% (8 of 13) of male breast cancer samples and 19% (10 of 52) of male gynecomastia samples screened. MMTV-like sequences were demonstrated in various premalignant breast lesions of females, including fibroadenoma (20%) and fibrocystic disease (28%) samples, at a significantly higher prevalence than that seen in normal breast tissue (1.8%; P = 0.00001). Study of a longitudinal cohort of female breast cancer patients indicated that MMTV was co-incident with tumor but was not present when tumor was absent on histology. These results support the association of MMTV-like sequences with development of breast tumors in men and women and suggest association of MMTV with increasing severity of cancer.}}, author = {{Ford, Caroline and Faedo, Margaret and Crouch, Roger and Lawson, James S and Rawlinson, William D}}, issn = {{1538-7445}}, language = {{eng}}, number = {{14}}, pages = {{4755--4759}}, publisher = {{American Association for Cancer Research Inc.}}, series = {{Cancer Research}}, title = {{Progression from normal breast pathology to breast cancer is associated with increasing prevalence of mouse mammary tumor virus-like sequences in men and women}}, url = {{http://dx.doi.org/10.1158/0008-5472.CAN-03-3804}}, doi = {{10.1158/0008-5472.CAN-03-3804}}, volume = {{64}}, year = {{2004}}, }