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Prostate-specific antigen and related isoforms in the diagnosis and management of prostate cancer

Haese, Alexander; Graefen, Markus; Huland, Hartwig and Lilja, Hans LU (2004) In Current Urology Reports 5(3). p.231-240
Abstract
Despite its unparalleled merits for prostate cancer detection and staging, prostate-specific antigen (PSA) is not a marker for prostate cancer only, but also is expressed in benign conditions. For early detection, limitations of PSA are obvious. Its widespread use has led to an extensive amount of expensive and often unnecessary diagnostic procedures associated with significant morbidity. Total PSA derivatives may enhance the accuracy of prostate cancer diagnosis. The ratio of free-to-total PSA improves specificity while maintaining a high sensitivity for prostate cancer detection for men with a total PSA of 2.5 to 10 ng/mL. Human glandular kallikrein also has the potential to be a valuable tool in combination with total and free PSA for... (More)
Despite its unparalleled merits for prostate cancer detection and staging, prostate-specific antigen (PSA) is not a marker for prostate cancer only, but also is expressed in benign conditions. For early detection, limitations of PSA are obvious. Its widespread use has led to an extensive amount of expensive and often unnecessary diagnostic procedures associated with significant morbidity. Total PSA derivatives may enhance the accuracy of prostate cancer diagnosis. The ratio of free-to-total PSA improves specificity while maintaining a high sensitivity for prostate cancer detection for men with a total PSA of 2.5 to 10 ng/mL. Human glandular kallikrein also has the potential to be a valuable tool in combination with total and free PSA for early diagnosis of prostate cancer. Complex PSA seems to be a reliable tool to improve specificity at high sensitivity levels in men with suspected prostate cancer (mainly in PSA levels below 4 ng/mL). Newly discovered isoforms of free PSA also may impact early detection of prostate cancer with encouraging preliminary results that warrant further clinical investigation. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Urology Reports
volume
5
issue
3
pages
231 - 240
publisher
Current Medicine Group LLC
external identifiers
  • pmid:15161573
  • scopus:4344703943
ISSN
1527-2737
DOI
10.1007/s11934-004-0042-6
language
English
LU publication?
no
id
28d27433-9edd-45b1-b8f6-f0ee71e7b762 (old id 1130068)
date added to LUP
2008-06-13 15:21:22
date last changed
2017-10-22 04:35:32
@article{28d27433-9edd-45b1-b8f6-f0ee71e7b762,
  abstract     = {Despite its unparalleled merits for prostate cancer detection and staging, prostate-specific antigen (PSA) is not a marker for prostate cancer only, but also is expressed in benign conditions. For early detection, limitations of PSA are obvious. Its widespread use has led to an extensive amount of expensive and often unnecessary diagnostic procedures associated with significant morbidity. Total PSA derivatives may enhance the accuracy of prostate cancer diagnosis. The ratio of free-to-total PSA improves specificity while maintaining a high sensitivity for prostate cancer detection for men with a total PSA of 2.5 to 10 ng/mL. Human glandular kallikrein also has the potential to be a valuable tool in combination with total and free PSA for early diagnosis of prostate cancer. Complex PSA seems to be a reliable tool to improve specificity at high sensitivity levels in men with suspected prostate cancer (mainly in PSA levels below 4 ng/mL). Newly discovered isoforms of free PSA also may impact early detection of prostate cancer with encouraging preliminary results that warrant further clinical investigation.},
  author       = {Haese, Alexander and Graefen, Markus and Huland, Hartwig and Lilja, Hans},
  issn         = {1527-2737},
  language     = {eng},
  number       = {3},
  pages        = {231--240},
  publisher    = {Current Medicine Group LLC},
  series       = {Current Urology Reports},
  title        = {Prostate-specific antigen and related isoforms in the diagnosis and management of prostate cancer},
  url          = {http://dx.doi.org/10.1007/s11934-004-0042-6},
  volume       = {5},
  year         = {2004},
}