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IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes.

von Pawel-Rammingen, Ulrich LU and Björck, Lars LU (2003) In Current Opinion in Microbiology 6(1). p.50-55
Abstract
The Gram-positive bacterium Streptococcus pyogenes is a major human pathogen causing substantial morbidity and mortality in society. S. pyogenes has evolved numerous molecular mechanisms to avoid the various actions of the human immune system and has established means to modulate both adaptive and innate immune responses. S. pyogenes produces and secretes proteolytic enzymes, which have an important impact on the ability of the bacteria to survive in the human host. Prominent among these are two immunoglobulin-degrading enzymes: the newly discovered streptococcal cysteine proteinase, IdeS, and the classical cysteine proteinase of S. pyogenes, SpeB.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Microbiology
volume
6
issue
1
pages
50 - 55
publisher
Elsevier
external identifiers
  • wos:000182300600008
  • pmid:12615219
  • scopus:0037330259
ISSN
1879-0364
DOI
10.1016/S1369-5274(03)00003-1
language
English
LU publication?
yes
id
f9c2fcc1-1af4-4bb5-bb18-8ecd506be5b8 (old id 113010)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12615219&dopt=Abstract
date added to LUP
2007-06-26 13:44:15
date last changed
2018-02-11 03:24:50
@article{f9c2fcc1-1af4-4bb5-bb18-8ecd506be5b8,
  abstract     = {The Gram-positive bacterium Streptococcus pyogenes is a major human pathogen causing substantial morbidity and mortality in society. S. pyogenes has evolved numerous molecular mechanisms to avoid the various actions of the human immune system and has established means to modulate both adaptive and innate immune responses. S. pyogenes produces and secretes proteolytic enzymes, which have an important impact on the ability of the bacteria to survive in the human host. Prominent among these are two immunoglobulin-degrading enzymes: the newly discovered streptococcal cysteine proteinase, IdeS, and the classical cysteine proteinase of S. pyogenes, SpeB.},
  author       = {von Pawel-Rammingen, Ulrich and Björck, Lars},
  issn         = {1879-0364},
  language     = {eng},
  number       = {1},
  pages        = {50--55},
  publisher    = {Elsevier},
  series       = {Current Opinion in Microbiology},
  title        = {IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes.},
  url          = {http://dx.doi.org/10.1016/S1369-5274(03)00003-1},
  volume       = {6},
  year         = {2003},
}