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Assessment of microvessel density in core needle biopsy specimen in breast cancer

Rydén, Lisa LU ; Boiesen, Poul and Jonsson, Per-Ebbe (2004) In Anticancer Research 24(1). p.371-375
Abstract
AIM: Estimation of microvessel density (MVD) in primary breast cancer in core needle biopsies (CNB) may predict response to systemic therapy. The aim of the present study was to explore the accuracy of assessment of MVD in CNB related to MVD in excised tumours. MATERIAL AND METHODS: MVD was estimated in core biopsies and subsequently excised tumours in 54 consecutive patients with breast cancer without pre-operative treatment. RESULTS: The correlation between MVD in CNB and excised tumours was non-significant. However, in tumours larger than 20 mm (r=0.56, p=0.005) and in lobular carcinomas (r=0.55, p=0.014) a significant correlation was observed. CONCLUSION: The overall accuracy between estimation of MVD on CNB and excised breast tumours... (More)
AIM: Estimation of microvessel density (MVD) in primary breast cancer in core needle biopsies (CNB) may predict response to systemic therapy. The aim of the present study was to explore the accuracy of assessment of MVD in CNB related to MVD in excised tumours. MATERIAL AND METHODS: MVD was estimated in core biopsies and subsequently excised tumours in 54 consecutive patients with breast cancer without pre-operative treatment. RESULTS: The correlation between MVD in CNB and excised tumours was non-significant. However, in tumours larger than 20 mm (r=0.56, p=0.005) and in lobular carcinomas (r=0.55, p=0.014) a significant correlation was observed. CONCLUSION: The overall accuracy between estimation of MVD on CNB and excised breast tumours was non-significant. The usefulness of MVD in CNB as a marker of response to systemic therapy should be further validated before it can be used in clinical practice. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer Research
volume
24
issue
1
pages
371 - 375
publisher
International Institute of Cancer Research
external identifiers
  • pmid:15015623
  • scopus:1442350508
ISSN
1791-7530
language
English
LU publication?
yes
id
a7f8a16c-d21a-4f36-98d1-2629a054f2a8 (old id 1130432)
date added to LUP
2008-06-17 14:39:07
date last changed
2017-01-01 04:38:07
@article{a7f8a16c-d21a-4f36-98d1-2629a054f2a8,
  abstract     = {AIM: Estimation of microvessel density (MVD) in primary breast cancer in core needle biopsies (CNB) may predict response to systemic therapy. The aim of the present study was to explore the accuracy of assessment of MVD in CNB related to MVD in excised tumours. MATERIAL AND METHODS: MVD was estimated in core biopsies and subsequently excised tumours in 54 consecutive patients with breast cancer without pre-operative treatment. RESULTS: The correlation between MVD in CNB and excised tumours was non-significant. However, in tumours larger than 20 mm (r=0.56, p=0.005) and in lobular carcinomas (r=0.55, p=0.014) a significant correlation was observed. CONCLUSION: The overall accuracy between estimation of MVD on CNB and excised breast tumours was non-significant. The usefulness of MVD in CNB as a marker of response to systemic therapy should be further validated before it can be used in clinical practice.},
  author       = {Rydén, Lisa and Boiesen, Poul and Jonsson, Per-Ebbe},
  issn         = {1791-7530},
  language     = {eng},
  number       = {1},
  pages        = {371--375},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Assessment of microvessel density in core needle biopsy specimen in breast cancer},
  volume       = {24},
  year         = {2004},
}