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D-dimer testing in patients with suspected acute thromboembolic occlusion of the superior mesenteric artery

Acosta, Stefan LU ; Nilsson, T K and Bjorck, M (2004) In British Journal of Surgery 91(8). p.991-994
Abstract
BACKGROUND: There is no accurate non-invasive method available for the diagnosis of acute thromboembolic occlusion of the superior mesenteric artery (SMA). The aim of this study was to assess the diagnostic properties of the fibrinolytic marker D-dimer. METHODS: From September 2000 to April 2003 consecutive patients aged over 50 years admitted to hospital with acute abdominal pain were studied. Patients with possible acute SMA occlusion at presentation had blood samples taken within 24 h of the onset of the pain for analysis of D-dimer, plasma fibrinogen, activated partial thromboplastin time, prothrombin time and antithrombin. The value of D-dimer testing to diagnose SMA occlusion was assessed by means of likelihood ratios. RESULTS: Nine... (More)
BACKGROUND: There is no accurate non-invasive method available for the diagnosis of acute thromboembolic occlusion of the superior mesenteric artery (SMA). The aim of this study was to assess the diagnostic properties of the fibrinolytic marker D-dimer. METHODS: From September 2000 to April 2003 consecutive patients aged over 50 years admitted to hospital with acute abdominal pain were studied. Patients with possible acute SMA occlusion at presentation had blood samples taken within 24 h of the onset of the pain for analysis of D-dimer, plasma fibrinogen, activated partial thromboplastin time, prothrombin time and antithrombin. The value of D-dimer testing to diagnose SMA occlusion was assessed by means of likelihood ratios. RESULTS: Nine of 101 patients included had acute SMA occlusion. The median D-dimer concentration was 1.6 (range 0.4-5.6) mg/l, which was higher than that in 25 patients with inflammatory disease (P = 0.007) or in 14 patients with intestinal obstruction (P = 0.005). The combination of a D-dimer level greater than 1.5 mg/l, atrial fibrillation and female sex resulted in a likelihood ratio for acute SMA occlusion of 17.5, whereas no patient with a D-dimer concentration of 0.3 mg/l or less had acute SMA occlusion. CONCLUSION: D-dimer testing may be useful for the exclusion of patients with suspected acute SMA occlusion. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
91
issue
8
pages
991 - 994
publisher
John Wiley & Sons
external identifiers
  • pmid:15286959
  • scopus:4043082730
ISSN
1365-2168
DOI
10.1002/bjs.4645
language
English
LU publication?
no
id
48a97be5-b5d2-4309-a65c-f62cc9671803 (old id 1130866)
date added to LUP
2008-06-12 11:02:07
date last changed
2017-09-24 03:49:03
@article{48a97be5-b5d2-4309-a65c-f62cc9671803,
  abstract     = {BACKGROUND: There is no accurate non-invasive method available for the diagnosis of acute thromboembolic occlusion of the superior mesenteric artery (SMA). The aim of this study was to assess the diagnostic properties of the fibrinolytic marker D-dimer. METHODS: From September 2000 to April 2003 consecutive patients aged over 50 years admitted to hospital with acute abdominal pain were studied. Patients with possible acute SMA occlusion at presentation had blood samples taken within 24 h of the onset of the pain for analysis of D-dimer, plasma fibrinogen, activated partial thromboplastin time, prothrombin time and antithrombin. The value of D-dimer testing to diagnose SMA occlusion was assessed by means of likelihood ratios. RESULTS: Nine of 101 patients included had acute SMA occlusion. The median D-dimer concentration was 1.6 (range 0.4-5.6) mg/l, which was higher than that in 25 patients with inflammatory disease (P = 0.007) or in 14 patients with intestinal obstruction (P = 0.005). The combination of a D-dimer level greater than 1.5 mg/l, atrial fibrillation and female sex resulted in a likelihood ratio for acute SMA occlusion of 17.5, whereas no patient with a D-dimer concentration of 0.3 mg/l or less had acute SMA occlusion. CONCLUSION: D-dimer testing may be useful for the exclusion of patients with suspected acute SMA occlusion.},
  author       = {Acosta, Stefan and Nilsson, T K and Bjorck, M},
  issn         = {1365-2168},
  language     = {eng},
  number       = {8},
  pages        = {991--994},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Surgery},
  title        = {D-dimer testing in patients with suspected acute thromboembolic occlusion of the superior mesenteric artery},
  url          = {http://dx.doi.org/10.1002/bjs.4645},
  volume       = {91},
  year         = {2004},
}