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Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation

Singh, Umashankar; Fohn, Laurel E; Wakayama, Teruhiko; Ohgane, Jun; Steinhoff, Christine; Lipkowitz, Bettina; Schulz, Ralph; Orth, Annie; Ropers, H Hilger and Behringer, Richard R, et al. (2004) In Developmental Dynamics 230(1). p.149-164
Abstract
To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only... (More)
To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only one gene was shared between IHPD and Esx1 mutant, and cloned and Esx1 mutant placentas, respectively. These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy. (Less)
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publication status
published
subject
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Developmental Dynamics
volume
230
issue
1
pages
149 - 164
publisher
John Wiley & Sons
external identifiers
  • pmid:15108320
  • scopus:11144354460
ISSN
1097-0177
DOI
10.1002/dvdy.20024
language
English
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no
id
42eb01a3-b542-4337-b7a3-85d01df5db74 (old id 1131039)
date added to LUP
2008-06-17 16:42:47
date last changed
2017-04-09 03:45:46
@article{42eb01a3-b542-4337-b7a3-85d01df5db74,
  abstract     = {To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only one gene was shared between IHPD and Esx1 mutant, and cloned and Esx1 mutant placentas, respectively. These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy.},
  author       = {Singh, Umashankar and Fohn, Laurel E and Wakayama, Teruhiko and Ohgane, Jun and Steinhoff, Christine and Lipkowitz, Bettina and Schulz, Ralph and Orth, Annie and Ropers, H Hilger and Behringer, Richard R and Tanaka, Satoshi and Shiota, Kunio and Yanagimachi, Ryuzo and Nuber, Ulrike},
  issn         = {1097-0177},
  language     = {eng},
  number       = {1},
  pages        = {149--164},
  publisher    = {John Wiley & Sons},
  series       = {Developmental Dynamics},
  title        = {Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation},
  url          = {http://dx.doi.org/10.1002/dvdy.20024},
  volume       = {230},
  year         = {2004},
}