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TGF-alpha regulates TLR expression and function on epidermal keratinocytes

Miller, Lloyd S; Sørensen, Ole E LU ; Liu, Philip T; Jalian, H Ray; Eshtiaghpour, Deborah; Behmanesh, Behnaz E; Chung, Woosin; Starner, Timothy D; Kim, Jenny and Sieling, Peter A, et al. (2005) In Journal of Immunology 174(10). p.6137-6143
Abstract
The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function,... (More)
The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Immunology
volume
174
issue
10
pages
6137 - 6143
publisher
American Association of Immunologists
external identifiers
  • pmid:15879109
ISSN
1550-6606
language
English
LU publication?
no
id
a1fe3017-54db-44de-96b9-a01ac95c2076 (old id 1132208)
alternative location
http://www.jimmunol.org/cgi/content/full/174/10/6137
date added to LUP
2008-06-30 11:39:27
date last changed
2016-06-29 08:57:41
@article{a1fe3017-54db-44de-96b9-a01ac95c2076,
  abstract     = {The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces.},
  author       = {Miller, Lloyd S and Sørensen, Ole E and Liu, Philip T and Jalian, H Ray and Eshtiaghpour, Deborah and Behmanesh, Behnaz E and Chung, Woosin and Starner, Timothy D and Kim, Jenny and Sieling, Peter A and Ganz, Tomas and Modlin, Robert L},
  issn         = {1550-6606},
  language     = {eng},
  number       = {10},
  pages        = {6137--6143},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {TGF-alpha regulates TLR expression and function on epidermal keratinocytes},
  volume       = {174},
  year         = {2005},
}