TGF-alpha regulates TLR expression and function on epidermal keratinocytes
(2005) In Journal of Immunology 174(10). p.6137-6143- Abstract
- The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function,... (More)
- The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1132208
- author
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunology
- volume
- 174
- issue
- 10
- pages
- 6137 - 6143
- publisher
- American Association of Immunologists
- external identifiers
-
- pmid:15879109
- ISSN
- 1550-6606
- language
- English
- LU publication?
- no
- id
- a1fe3017-54db-44de-96b9-a01ac95c2076 (old id 1132208)
- alternative location
- http://www.jimmunol.org/cgi/content/full/174/10/6137
- date added to LUP
- 2016-04-01 16:16:19
- date last changed
- 2018-11-21 20:40:05
@article{a1fe3017-54db-44de-96b9-a01ac95c2076,
abstract = {{The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces.}},
author = {{Miller, Lloyd S and Sørensen, Ole E and Liu, Philip T and Jalian, H Ray and Eshtiaghpour, Deborah and Behmanesh, Behnaz E and Chung, Woosin and Starner, Timothy D and Kim, Jenny and Sieling, Peter A and Ganz, Tomas and Modlin, Robert L}},
issn = {{1550-6606}},
language = {{eng}},
number = {{10}},
pages = {{6137--6143}},
publisher = {{American Association of Immunologists}},
series = {{Journal of Immunology}},
title = {{TGF-alpha regulates TLR expression and function on epidermal keratinocytes}},
url = {{http://www.jimmunol.org/cgi/content/full/174/10/6137}},
volume = {{174}},
year = {{2005}},
}