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Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia

Rivera, Seth; Liu, Lide; Nemeth, Elizabeta; Gabayan, Victoria; Sørensen, Ole E LU and Ganz, Tomas (2005) In Blood 105(4). p.1797-1802
Abstract
The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 microg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from... (More)
The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 microg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
105
issue
4
pages
1797 - 1802
publisher
American Society of Hematology
external identifiers
  • pmid:15479721
  • scopus:13544252463
ISSN
1528-0020
DOI
10.1182/blood-2004-08-3375
language
English
LU publication?
no
id
f4e99571-8d7c-4873-8fed-66ee40b1c6fe (old id 1132236)
date added to LUP
2008-06-30 11:31:12
date last changed
2017-10-01 03:38:24
@article{f4e99571-8d7c-4873-8fed-66ee40b1c6fe,
  abstract     = {The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 microg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes.},
  author       = {Rivera, Seth and Liu, Lide and Nemeth, Elizabeta and Gabayan, Victoria and Sørensen, Ole E and Ganz, Tomas},
  issn         = {1528-0020},
  language     = {eng},
  number       = {4},
  pages        = {1797--1802},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia},
  url          = {http://dx.doi.org/10.1182/blood-2004-08-3375},
  volume       = {105},
  year         = {2005},
}