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Skewing Towards Neuroendocrine Phenotype in High Grade or High Stage Androgen-Responsive Primary Prostate Cancer

Puccetti, Luca; Supuran, Claudiu T; Fasolo, Pier P; Conti, Enrico; Sebastiani, Giancarlo; Lacquaniti, Sergio; Mandras, Roberto; Milazzo, Maria G; Dogliani, Natalia and De Giuli, Paolo, et al. (2005) In European Urology 48(2). p.215-223
Abstract
Objective:



The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration.

Methods:



Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies.

Results:



High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or... (More)
Objective:



The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration.

Methods:



Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies.

Results:



High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or localized diseases (p < 0.005). Both the CgA score of the surgical specimens and the PSA level in the serum increased linearly (p = 0.001). In the samples of many corresponding tumor biopsies no significant CgA staining was found.

Conclusion:



NE differentiation in primary untreated prostate cancer is closely associated with the major prognostic parameters of survival. This association cannot be shown by evaluating the CgA staining in tumor biopsies. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Neuroendocrine differentiation, Chromogranin A, High grade prostate cancer, High stage prostate cancer, Serum PSA, Prostatic biopsies
in
European Urology
volume
48
issue
2
pages
215 - 223
publisher
Elsevier
external identifiers
  • scopus:21844454221
ISSN
1873-7560
DOI
10.1016/j.eururo.2005.03.018
language
English
LU publication?
no
id
b9c2da89-1c18-440e-9c56-03b8f923eaa7 (old id 1132362)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/15992991
http://www.sciencedirect.com.ludwig.lub.lu.se/science/article/pii/S0302283805001521
date added to LUP
2013-10-16 15:13:01
date last changed
2017-01-01 07:28:23
@article{b9c2da89-1c18-440e-9c56-03b8f923eaa7,
  abstract     = {Objective:<br/><br>
<br/><br>
The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration.<br/><br>
Methods:<br/><br>
<br/><br>
Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies.<br/><br>
Results:<br/><br>
<br/><br>
High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or localized diseases (p &lt; 0.005). Both the CgA score of the surgical specimens and the PSA level in the serum increased linearly (p = 0.001). In the samples of many corresponding tumor biopsies no significant CgA staining was found.<br/><br>
Conclusion:<br/><br>
<br/><br>
NE differentiation in primary untreated prostate cancer is closely associated with the major prognostic parameters of survival. This association cannot be shown by evaluating the CgA staining in tumor biopsies.},
  author       = {Puccetti, Luca and Supuran, Claudiu T and Fasolo, Pier P and Conti, Enrico and Sebastiani, Giancarlo and Lacquaniti, Sergio and Mandras, Roberto and Milazzo, Maria G and Dogliani, Natalia and De Giuli, Paolo and Fasolis, Giuseppe},
  issn         = {1873-7560},
  keyword      = {Neuroendocrine differentiation,Chromogranin A,High grade prostate cancer,High stage prostate cancer,Serum PSA,Prostatic biopsies},
  language     = {eng},
  number       = {2},
  pages        = {215--223},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Skewing Towards Neuroendocrine Phenotype in High Grade or High Stage Androgen-Responsive Primary Prostate Cancer},
  url          = {http://dx.doi.org/10.1016/j.eururo.2005.03.018},
  volume       = {48},
  year         = {2005},
}