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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

Li, Xuri; Tjwa, Marc; Moons, Lieve; Fons, Pierre; Noel, Agnes; Ny, Annelii; Zhou, Jian Min; Lennartsson, Johan; Li, Hong and Luttun, Aernout, et al. (2005) In Journal of Clinical Investigation 115(1). p.118-127
Abstract
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
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type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Investigation
volume
115
issue
1
pages
118 - 127
publisher
The Journal of Clinical Investigation
external identifiers
  • pmid:15630451
  • scopus:13744260683
ISSN
0021-9738
DOI
10.1172/JCI200519189
language
English
LU publication?
no
id
120de287-e6de-46eb-92d4-22b73325e5f9 (old id 1132673)
date added to LUP
2008-06-27 11:46:51
date last changed
2017-10-22 04:36:35
@article{120de287-e6de-46eb-92d4-22b73325e5f9,
  abstract     = {The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.},
  author       = {Li, Xuri and Tjwa, Marc and Moons, Lieve and Fons, Pierre and Noel, Agnes and Ny, Annelii and Zhou, Jian Min and Lennartsson, Johan and Li, Hong and Luttun, Aernout and Pontén, Annica and Devy, Laetitia and Bouche, Ann and Oh, Hideyasu and Manderveld, Ann and Blacher, Silvia and Communi, Davi},
  issn         = {0021-9738},
  language     = {eng},
  number       = {1},
  pages        = {118--127},
  publisher    = {The Journal of Clinical Investigation},
  series       = {Journal of Clinical Investigation},
  title        = {Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors},
  url          = {http://dx.doi.org/10.1172/JCI200519189},
  volume       = {115},
  year         = {2005},
}