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Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.

Sommandas, V; Rutledge, E A; Van Yserloo, B; Fuller, J; Lernmark, Åke LU and Drexhage, H A (2005) In Journal of Autoimmunity 25(1). p.46-56
Abstract
BB rats develop various organ-specific autoimmune diseases, e.g. autoimmune diabetes and thyroiditis and have proven important to dissect genetic factors that govern autoimmune disease development. The lymphopenia (lyp) gene (iddm2) is linked to autoimmune disease development and is a major genetic difference between diabetes-resistant (DR) and diabetes-prone (DP) BB rats. To study the effects of the lyp gene and other genes on dendritic cell (DC) differentiation from bone-marrow precursors, such differentiation was studied in BB-DP, BB-DR, Wistar and F344 control rats.



DC of BB-DP rats showed a lower MHC class II expression as compared to BB-DR, Wistar and F344 rats. LPS-maturation did not restore this low MHC class II... (More)
BB rats develop various organ-specific autoimmune diseases, e.g. autoimmune diabetes and thyroiditis and have proven important to dissect genetic factors that govern autoimmune disease development. The lymphopenia (lyp) gene (iddm2) is linked to autoimmune disease development and is a major genetic difference between diabetes-resistant (DR) and diabetes-prone (DP) BB rats. To study the effects of the lyp gene and other genes on dendritic cell (DC) differentiation from bone-marrow precursors, such differentiation was studied in BB-DP, BB-DR, Wistar and F344 control rats.



DC of BB-DP rats showed a lower MHC class II expression as compared to BB-DR, Wistar and F344 rats. LPS-maturation did not restore this low MHC class II expression. DC of BB-DP rats also showed a poor capability to terminally differentiate into mature T cell stimulatory DC under the influence of LPS and produced significantly lower quantities of IL-10, yet these aberrancies were also found in BB-DR rats but did not occur in control rats.



This study thus shows that various aberrancies exist in the differentiation of myeloid DC from bone-marrow precursors in the BB rat model of organ-specific autoimmunity. These aberrancies are multigenically determined and partly associated with iddm2 (lyp gene) and partly associated with other genes in the BB rat. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dendritic cells, BB rat, lyp gene
in
Journal of Autoimmunity
volume
25
issue
1
pages
46 - 56
publisher
Elsevier
external identifiers
  • scopus:22444450680
ISSN
0896-8411
DOI
10.1016/j.jaut.2005.03.008
language
English
LU publication?
no
id
4f289d30-71cd-4b8d-bf80-dc94e146b4d1 (old id 1133085)
date added to LUP
2008-06-19 12:15:57
date last changed
2017-01-01 04:19:44
@article{4f289d30-71cd-4b8d-bf80-dc94e146b4d1,
  abstract     = {BB rats develop various organ-specific autoimmune diseases, e.g. autoimmune diabetes and thyroiditis and have proven important to dissect genetic factors that govern autoimmune disease development. The lymphopenia (lyp) gene (iddm2) is linked to autoimmune disease development and is a major genetic difference between diabetes-resistant (DR) and diabetes-prone (DP) BB rats. To study the effects of the lyp gene and other genes on dendritic cell (DC) differentiation from bone-marrow precursors, such differentiation was studied in BB-DP, BB-DR, Wistar and F344 control rats.<br/><br>
<br/><br>
DC of BB-DP rats showed a lower MHC class II expression as compared to BB-DR, Wistar and F344 rats. LPS-maturation did not restore this low MHC class II expression. DC of BB-DP rats also showed a poor capability to terminally differentiate into mature T cell stimulatory DC under the influence of LPS and produced significantly lower quantities of IL-10, yet these aberrancies were also found in BB-DR rats but did not occur in control rats.<br/><br>
<br/><br>
This study thus shows that various aberrancies exist in the differentiation of myeloid DC from bone-marrow precursors in the BB rat model of organ-specific autoimmunity. These aberrancies are multigenically determined and partly associated with iddm2 (lyp gene) and partly associated with other genes in the BB rat.},
  author       = {Sommandas, V and Rutledge, E A and Van Yserloo, B and Fuller, J and Lernmark, Åke and Drexhage, H A},
  issn         = {0896-8411},
  keyword      = {Dendritic cells,BB rat,lyp gene},
  language     = {eng},
  number       = {1},
  pages        = {46--56},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.},
  url          = {http://dx.doi.org/10.1016/j.jaut.2005.03.008},
  volume       = {25},
  year         = {2005},
}