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Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl

Jenei, Veronica LU ; Zor, K ; Magyar, K and Jakus, J (2005) In Journal of Neural Transmission 112(11). p.1433-1445
Abstract
The neuroprotective effect of the antiparkinsonian monoamine oxidase (MAO)-B inhibitor, R-(-)-deprenyl has been under investigation for years. Cytoskeleton, a main component of cell adhesion, is involved in the development of R-(-)-deprenyl-responsive diseases, the effect of the drug on cell adhesion, however, is not known. We examined the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal and non-neuronal cells. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 and NIH3T3 cells at concentrations lower than those required for MAO-B inhibition, while S-(+)-deprenyl was not effective. This acitvity of R-(-)-deprenyl was not prevented by the cytochrome P-450 inhibitor,... (More)
The neuroprotective effect of the antiparkinsonian monoamine oxidase (MAO)-B inhibitor, R-(-)-deprenyl has been under investigation for years. Cytoskeleton, a main component of cell adhesion, is involved in the development of R-(-)-deprenyl-responsive diseases, the effect of the drug on cell adhesion, however, is not known. We examined the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal and non-neuronal cells. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 and NIH3T3 cells at concentrations lower than those required for MAO-B inhibition, while S-(+)-deprenyl was not effective. This acitvity of R-(-)-deprenyl was not prevented by the cytochrome P-450 inhibitor, SKF525A, while deprenyl-N-oxide, a newly described metabolite, also induced an increase in cell-cell adhesion. The effect of R-(-)-deprenyl was not reversible during a 24-hour recovery period. In summary, we described a new, MAO-B independent effect of R-(-)-deprenyl on cell-cell adhesion which can contribute to its neuroprotective function. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neural Transmission
volume
112
issue
11
pages
1433 - 1445
publisher
Springer
external identifiers
  • pmid:15785858
  • scopus:27144488651
ISSN
0300-9564
DOI
10.1007/s00702-005-0295-3
language
English
LU publication?
yes
id
fb702379-be4a-4517-bc86-15f3caff2fa6 (old id 1133166)
date added to LUP
2016-04-01 15:36:52
date last changed
2022-05-08 04:37:39
@article{fb702379-be4a-4517-bc86-15f3caff2fa6,
  abstract     = {{The neuroprotective effect of the antiparkinsonian monoamine oxidase (MAO)-B inhibitor, R-(-)-deprenyl has been under investigation for years. Cytoskeleton, a main component of cell adhesion, is involved in the development of R-(-)-deprenyl-responsive diseases, the effect of the drug on cell adhesion, however, is not known. We examined the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal and non-neuronal cells. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 and NIH3T3 cells at concentrations lower than those required for MAO-B inhibition, while S-(+)-deprenyl was not effective. This acitvity of R-(-)-deprenyl was not prevented by the cytochrome P-450 inhibitor, SKF525A, while deprenyl-N-oxide, a newly described metabolite, also induced an increase in cell-cell adhesion. The effect of R-(-)-deprenyl was not reversible during a 24-hour recovery period. In summary, we described a new, MAO-B independent effect of R-(-)-deprenyl on cell-cell adhesion which can contribute to its neuroprotective function.}},
  author       = {{Jenei, Veronica and Zor, K and Magyar, K and Jakus, J}},
  issn         = {{0300-9564}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1433--1445}},
  publisher    = {{Springer}},
  series       = {{Journal of Neural Transmission}},
  title        = {{Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl}},
  url          = {{http://dx.doi.org/10.1007/s00702-005-0295-3}},
  doi          = {{10.1007/s00702-005-0295-3}},
  volume       = {{112}},
  year         = {{2005}},
}