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Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl

Jenei, Veronica LU ; Zor, K; Magyar, K and Jakus, J (2005) In Journal of Neural Transmission 112(11). p.1433-1445
Abstract
The neuroprotective effect of the antiparkinsonian monoamine oxidase (MAO)-B inhibitor, R-(-)-deprenyl has been under investigation for years. Cytoskeleton, a main component of cell adhesion, is involved in the development of R-(-)-deprenyl-responsive diseases, the effect of the drug on cell adhesion, however, is not known. We examined the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal and non-neuronal cells. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 and NIH3T3 cells at concentrations lower than those required for MAO-B inhibition, while S-(+)-deprenyl was not effective. This acitvity of R-(-)-deprenyl was not prevented by the cytochrome P-450 inhibitor,... (More)
The neuroprotective effect of the antiparkinsonian monoamine oxidase (MAO)-B inhibitor, R-(-)-deprenyl has been under investigation for years. Cytoskeleton, a main component of cell adhesion, is involved in the development of R-(-)-deprenyl-responsive diseases, the effect of the drug on cell adhesion, however, is not known. We examined the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal and non-neuronal cells. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 and NIH3T3 cells at concentrations lower than those required for MAO-B inhibition, while S-(+)-deprenyl was not effective. This acitvity of R-(-)-deprenyl was not prevented by the cytochrome P-450 inhibitor, SKF525A, while deprenyl-N-oxide, a newly described metabolite, also induced an increase in cell-cell adhesion. The effect of R-(-)-deprenyl was not reversible during a 24-hour recovery period. In summary, we described a new, MAO-B independent effect of R-(-)-deprenyl on cell-cell adhesion which can contribute to its neuroprotective function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neural Transmission
volume
112
issue
11
pages
1433 - 1445
publisher
Springer
external identifiers
  • pmid:15785858
  • scopus:27144488651
ISSN
0300-9564
DOI
10.1007/s00702-005-0295-3
language
English
LU publication?
yes
id
fb702379-be4a-4517-bc86-15f3caff2fa6 (old id 1133166)
date added to LUP
2008-06-19 11:32:30
date last changed
2017-01-01 06:43:09
@article{fb702379-be4a-4517-bc86-15f3caff2fa6,
  abstract     = {The neuroprotective effect of the antiparkinsonian monoamine oxidase (MAO)-B inhibitor, R-(-)-deprenyl has been under investigation for years. Cytoskeleton, a main component of cell adhesion, is involved in the development of R-(-)-deprenyl-responsive diseases, the effect of the drug on cell adhesion, however, is not known. We examined the effect of R-(-)-deprenyl on cell-cell adhesion of neuronal and non-neuronal cells. R-(-)-deprenyl treatment resulted in a cell type- and concentration-dependent increase in cell-cell adhesion of PC12 and NIH3T3 cells at concentrations lower than those required for MAO-B inhibition, while S-(+)-deprenyl was not effective. This acitvity of R-(-)-deprenyl was not prevented by the cytochrome P-450 inhibitor, SKF525A, while deprenyl-N-oxide, a newly described metabolite, also induced an increase in cell-cell adhesion. The effect of R-(-)-deprenyl was not reversible during a 24-hour recovery period. In summary, we described a new, MAO-B independent effect of R-(-)-deprenyl on cell-cell adhesion which can contribute to its neuroprotective function.},
  author       = {Jenei, Veronica and Zor, K and Magyar, K and Jakus, J},
  issn         = {0300-9564},
  language     = {eng},
  number       = {11},
  pages        = {1433--1445},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl},
  url          = {http://dx.doi.org/10.1007/s00702-005-0295-3},
  volume       = {112},
  year         = {2005},
}