The role of EGF receptor-dependent e3B1/Abi1 protein as a tumor suppressor protein in malignant tumors
(2005) In Orvosi Hetilap 146(24). p.9-1293- Abstract
- Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inhibit intracellular signalling processes that under pathophysiological conditions can lead to uncontrolled cell proliferation and tumour formation. Protein e3B1/Abi-1, which belongs to the family of Abl-interactors, was isolated recently as a possible tumour suppressor. As a partner of Abl kinase, its role has been investigated in the development... (More)
- Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inhibit intracellular signalling processes that under pathophysiological conditions can lead to uncontrolled cell proliferation and tumour formation. Protein e3B1/Abi-1, which belongs to the family of Abl-interactors, was isolated recently as a possible tumour suppressor. As a partner of Abl kinase, its role has been investigated in the development and progression of some types of leukemias, however, more and more experimental data suggest that it is a general suppressor protein. According to the latest results, e3B1/Abi-1 via the Ras small G-protein has an essential role in the regulation of cel (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1133180
- author
- Jenei, Veronica LU and Jakus, J
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Orvosi Hetilap
- volume
- 146
- issue
- 24
- pages
- 9 - 1293
- publisher
- Akademiai Kiado
- external identifiers
-
- scopus:24144492401
- ISSN
- 0030-6002
- language
- English
- LU publication?
- yes
- id
- 050d1e94-687d-4c41-a3f4-8c126dad7876 (old id 1133180)
- date added to LUP
- 2016-04-01 17:07:48
- date last changed
- 2022-03-15 05:21:24
@article{050d1e94-687d-4c41-a3f4-8c126dad7876,
abstract = {{Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inhibit intracellular signalling processes that under pathophysiological conditions can lead to uncontrolled cell proliferation and tumour formation. Protein e3B1/Abi-1, which belongs to the family of Abl-interactors, was isolated recently as a possible tumour suppressor. As a partner of Abl kinase, its role has been investigated in the development and progression of some types of leukemias, however, more and more experimental data suggest that it is a general suppressor protein. According to the latest results, e3B1/Abi-1 via the Ras small G-protein has an essential role in the regulation of cel}},
author = {{Jenei, Veronica and Jakus, J}},
issn = {{0030-6002}},
language = {{eng}},
number = {{24}},
pages = {{9--1293}},
publisher = {{Akademiai Kiado}},
series = {{Orvosi Hetilap}},
title = {{The role of EGF receptor-dependent e3B1/Abi1 protein as a tumor suppressor protein in malignant tumors}},
volume = {{146}},
year = {{2005}},
}