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The role of EGF receptor-dependent e3B1/Abi1 protein as a tumor suppressor protein in malignant tumors

Jenei, Veronica LU and Jakus, J (2005) In Orvosi Hetilap 146(24). p.9-1293
Abstract
Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inhibit intracellular signalling processes that under pathophysiological conditions can lead to uncontrolled cell proliferation and tumour formation. Protein e3B1/Abi-1, which belongs to the family of Abl-interactors, was isolated recently as a possible tumour suppressor. As a partner of Abl kinase, its role has been investigated in the development... (More)
Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inhibit intracellular signalling processes that under pathophysiological conditions can lead to uncontrolled cell proliferation and tumour formation. Protein e3B1/Abi-1, which belongs to the family of Abl-interactors, was isolated recently as a possible tumour suppressor. As a partner of Abl kinase, its role has been investigated in the development and progression of some types of leukemias, however, more and more experimental data suggest that it is a general suppressor protein. According to the latest results, e3B1/Abi-1 via the Ras small G-protein has an essential role in the regulation of cel (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Orvosi Hetilap
volume
146
issue
24
pages
9 - 1293
publisher
Akademiai Kiado
ISSN
0030-6002
language
English
LU publication?
yes
id
050d1e94-687d-4c41-a3f4-8c126dad7876 (old id 1133180)
date added to LUP
2008-06-19 11:39:53
date last changed
2016-04-16 05:24:35
@article{050d1e94-687d-4c41-a3f4-8c126dad7876,
  abstract     = {Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inhibit intracellular signalling processes that under pathophysiological conditions can lead to uncontrolled cell proliferation and tumour formation. Protein e3B1/Abi-1, which belongs to the family of Abl-interactors, was isolated recently as a possible tumour suppressor. As a partner of Abl kinase, its role has been investigated in the development and progression of some types of leukemias, however, more and more experimental data suggest that it is a general suppressor protein. According to the latest results, e3B1/Abi-1 via the Ras small G-protein has an essential role in the regulation of cel},
  author       = {Jenei, Veronica and Jakus, J},
  issn         = {0030-6002},
  language     = {eng},
  number       = {24},
  pages        = {9--1293},
  publisher    = {Akademiai Kiado},
  series       = {Orvosi Hetilap},
  title        = {The role of EGF receptor-dependent e3B1/Abi1 protein as a tumor suppressor protein in malignant tumors},
  volume       = {146},
  year         = {2005},
}