Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE
(2005) In Nitric Oxide 13(3). p.188-195- Abstract
- Hypothesising that systemically and intrathecally produced nitric oxide might play different roles in the EAE pathogenesis, we administered the NOS inhibitor N-nitro-methyl-L-arginine-ester intrathecally or systemically via osmotic minipumps to DA rats with MOG induced EAE. We demonstrate an protective effect of the NOS inhibitor on EAE severity, the extent of CNS inflammation, and demyelination. Intrathecal administration was more effective when compared to systemic administration. The observed effect was accompanied by enhanced anti-MOG IgG1 production. In our model, the therapeutic effect was concluded to be due to direct inhibition of the NO pathway in the CNS.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1133193
- author
- Danilov, Alexandre LU ; Jagodic, Maja ; Wiklund, N Peter ; Olsson, Tomas and Brundin, Lou
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Experimental autoimmune encephalomyelitis, Nitric oxide, iNOS inhibitor, Multiple sclerosis
- in
- Nitric Oxide
- volume
- 13
- issue
- 3
- pages
- 188 - 195
- publisher
- Elsevier
- external identifiers
-
- pmid:16102987
- scopus:26644463012
- ISSN
- 1089-8603
- DOI
- 10.1016/j.niox.2005.06.007
- language
- English
- LU publication?
- no
- id
- 72fb3e0e-4dd5-47d1-bbb0-5e38965a997d (old id 1133193)
- date added to LUP
- 2016-04-01 11:45:11
- date last changed
- 2024-01-07 19:12:15
@article{72fb3e0e-4dd5-47d1-bbb0-5e38965a997d, abstract = {{Hypothesising that systemically and intrathecally produced nitric oxide might play different roles in the EAE pathogenesis, we administered the NOS inhibitor N-nitro-methyl-L-arginine-ester intrathecally or systemically via osmotic minipumps to DA rats with MOG induced EAE. We demonstrate an protective effect of the NOS inhibitor on EAE severity, the extent of CNS inflammation, and demyelination. Intrathecal administration was more effective when compared to systemic administration. The observed effect was accompanied by enhanced anti-MOG IgG1 production. In our model, the therapeutic effect was concluded to be due to direct inhibition of the NO pathway in the CNS.}}, author = {{Danilov, Alexandre and Jagodic, Maja and Wiklund, N Peter and Olsson, Tomas and Brundin, Lou}}, issn = {{1089-8603}}, keywords = {{Experimental autoimmune encephalomyelitis; Nitric oxide; iNOS inhibitor; Multiple sclerosis}}, language = {{eng}}, number = {{3}}, pages = {{188--195}}, publisher = {{Elsevier}}, series = {{Nitric Oxide}}, title = {{Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE}}, url = {{http://dx.doi.org/10.1016/j.niox.2005.06.007}}, doi = {{10.1016/j.niox.2005.06.007}}, volume = {{13}}, year = {{2005}}, }