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Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE

Danilov, Alexandre LU ; Jagodic, Maja; Wiklund, N Peter; Olsson, Tomas and Brundin, Lou (2005) In Nitric Oxide 13(3). p.188-195
Abstract
Hypothesising that systemically and intrathecally produced nitric oxide might play different roles in the EAE pathogenesis, we administered the NOS inhibitor N-nitro-methyl-L-arginine-ester intrathecally or systemically via osmotic minipumps to DA rats with MOG induced EAE. We demonstrate an protective effect of the NOS inhibitor on EAE severity, the extent of CNS inflammation, and demyelination. Intrathecal administration was more effective when compared to systemic administration. The observed effect was accompanied by enhanced anti-MOG IgG1 production. In our model, the therapeutic effect was concluded to be due to direct inhibition of the NO pathway in the CNS.
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Experimental autoimmune encephalomyelitis, Nitric oxide, iNOS inhibitor, Multiple sclerosis
in
Nitric Oxide
volume
13
issue
3
pages
188 - 195
publisher
Elsevier
external identifiers
  • pmid:16102987
  • scopus:26644463012
ISSN
1089-8603
DOI
10.1016/j.niox.2005.06.007
language
English
LU publication?
no
id
72fb3e0e-4dd5-47d1-bbb0-5e38965a997d (old id 1133193)
date added to LUP
2008-06-25 08:39:20
date last changed
2017-01-22 03:24:31
@article{72fb3e0e-4dd5-47d1-bbb0-5e38965a997d,
  abstract     = {Hypothesising that systemically and intrathecally produced nitric oxide might play different roles in the EAE pathogenesis, we administered the NOS inhibitor N-nitro-methyl-L-arginine-ester intrathecally or systemically via osmotic minipumps to DA rats with MOG induced EAE. We demonstrate an protective effect of the NOS inhibitor on EAE severity, the extent of CNS inflammation, and demyelination. Intrathecal administration was more effective when compared to systemic administration. The observed effect was accompanied by enhanced anti-MOG IgG1 production. In our model, the therapeutic effect was concluded to be due to direct inhibition of the NO pathway in the CNS.},
  author       = {Danilov, Alexandre and Jagodic, Maja and Wiklund, N Peter and Olsson, Tomas and Brundin, Lou},
  issn         = {1089-8603},
  keyword      = {Experimental autoimmune encephalomyelitis,Nitric oxide,iNOS inhibitor,Multiple sclerosis},
  language     = {eng},
  number       = {3},
  pages        = {188--195},
  publisher    = {Elsevier},
  series       = {Nitric Oxide},
  title        = {Effects of long term NOS inhibition on disease and the immune system in MOG induced EAE},
  url          = {http://dx.doi.org/10.1016/j.niox.2005.06.007},
  volume       = {13},
  year         = {2005},
}