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Osteoarthritis - an update

Lohmander, Stefan LU (2005) In Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents 4(3). p.209-215
Abstract
Osteoarthritis (sometimes called “arthrosis” or “osteoarthrosis”) often entails a slow and gradual deterioration of the joint that may sometimes lead to its total destruction and the need for an operation to replace it. However, for most patients with osteoarthritis, surgical treatment never becomes necessary, and their symptoms can be dealt with satisfactorily by self management, by non-pharmacological treatment or by pharmacological treatment. Osteoarthritis is not one single disease, but should rather be seen as a common final stage, joint failure, where the initial stages of the disease process can be triggered by many different causes. The main symptoms are joint pain, stiffness and limited mobility, which may lead to impairment and... (More)
Osteoarthritis (sometimes called “arthrosis” or “osteoarthrosis”) often entails a slow and gradual deterioration of the joint that may sometimes lead to its total destruction and the need for an operation to replace it. However, for most patients with osteoarthritis, surgical treatment never becomes necessary, and their symptoms can be dealt with satisfactorily by self management, by non-pharmacological treatment or by pharmacological treatment. Osteoarthritis is not one single disease, but should rather be seen as a common final stage, joint failure, where the initial stages of the disease process can be triggered by many different causes. The main symptoms are joint pain, stiffness and limited mobility, which may lead to impairment and handicap. When the disease is far advanced an X-ray examination will show signs in the form of reduced joint space and osteophytes. These changes to the structure of the joint are caused by the destruction of the articular cartilage and the growth of bone deposits at the margins of the joints. Today there is no treatment which can stop the progress of the arthritic disease and joint destruction in osteoarthritis, but there is a series of treatments which can reduce the pain and help to maintain or improve function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tumour necrosis factor alpha, interleukin, proteolytic enzymes, arthrosis, cartilage, x-ray examination
in
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents
volume
4
issue
3
pages
209 - 215
publisher
Bentham Science Publishers
external identifiers
  • scopus:20844444762
ISSN
1568-0142
DOI
10.2174/1568014054065221
language
English
LU publication?
yes
id
5ccb47eb-9538-4b65-aec2-66b14893467f (old id 1133459)
date added to LUP
2008-06-25 12:00:10
date last changed
2017-01-01 07:16:08
@article{5ccb47eb-9538-4b65-aec2-66b14893467f,
  abstract     = {Osteoarthritis (sometimes called “arthrosis” or “osteoarthrosis”) often entails a slow and gradual deterioration of the joint that may sometimes lead to its total destruction and the need for an operation to replace it. However, for most patients with osteoarthritis, surgical treatment never becomes necessary, and their symptoms can be dealt with satisfactorily by self management, by non-pharmacological treatment or by pharmacological treatment. Osteoarthritis is not one single disease, but should rather be seen as a common final stage, joint failure, where the initial stages of the disease process can be triggered by many different causes. The main symptoms are joint pain, stiffness and limited mobility, which may lead to impairment and handicap. When the disease is far advanced an X-ray examination will show signs in the form of reduced joint space and osteophytes. These changes to the structure of the joint are caused by the destruction of the articular cartilage and the growth of bone deposits at the margins of the joints. Today there is no treatment which can stop the progress of the arthritic disease and joint destruction in osteoarthritis, but there is a series of treatments which can reduce the pain and help to maintain or improve function.},
  author       = {Lohmander, Stefan},
  issn         = {1568-0142},
  keyword      = {tumour necrosis factor alpha,interleukin,proteolytic enzymes,arthrosis,cartilage,x-ray examination},
  language     = {eng},
  number       = {3},
  pages        = {209--215},
  publisher    = {Bentham Science Publishers},
  series       = {Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents},
  title        = {Osteoarthritis - an update},
  url          = {http://dx.doi.org/10.2174/1568014054065221},
  volume       = {4},
  year         = {2005},
}