Advanced

How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches

Biro, T; Ko, M C; Bromm, B; Wei, E T; Bigliardi, P; Siebenhaar, F; Hashizume, H; Misery, L; Bergasa, N V and Kamei, C, et al. (2005) In Experimental Dermatology 14(3). p.225-225
Abstract
While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic 'itch' on the quality of life of an affected individual are widely appreciated, the complexity of this sensation is still often grossly underestimated. The current Controversies feature highlights this complexity by portraying pruritus as a truly interdisciplinary problem at the crossroads of neurophysiology, neuroimmunology, neuropharmacology, protease research, internal medicine, and dermatology, which is combated most successfully if one keeps the multilayered nature of 'itch' in mind and adopts a holistic treatment approach - beyond the customary, frequently frustrane monotherapy with histamine receptor... (More)
While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic 'itch' on the quality of life of an affected individual are widely appreciated, the complexity of this sensation is still often grossly underestimated. The current Controversies feature highlights this complexity by portraying pruritus as a truly interdisciplinary problem at the crossroads of neurophysiology, neuroimmunology, neuropharmacology, protease research, internal medicine, and dermatology, which is combated most successfully if one keeps the multilayered nature of 'itch' in mind and adopts a holistic treatment approach - beyond the customary, frequently frustrane monotherapy with histamine receptor antagonists. In view of the often unsatisfactory, unidimensional, and altogether rather crude standard instruments for pruritus management that we still tend to use in clinical practice today, an interdisciplinary team of pruritus experts here critically examines recent progress in pruritus research that future itch management must take into consideration. Focusing on new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus, and discussing available neuropharmacological tools, specific research avenues are highlighted, whose pursuit promises to lead to novel, and hopefully more effective, forms of pruritus management. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Dermatology
volume
14
issue
3
pages
225 - 225
publisher
Wiley-Blackwell
external identifiers
  • pmid:15740597
  • scopus:20144386128
ISSN
0906-6705
DOI
10.1111/j.0906-6705.2005.0321a.x
language
English
LU publication?
yes
id
e5b67aa7-c5fc-47a4-98da-ef7c587a5e21 (old id 1133647)
date added to LUP
2008-06-17 15:46:36
date last changed
2017-08-27 04:14:16
@article{e5b67aa7-c5fc-47a4-98da-ef7c587a5e21,
  abstract     = {While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic 'itch' on the quality of life of an affected individual are widely appreciated, the complexity of this sensation is still often grossly underestimated. The current Controversies feature highlights this complexity by portraying pruritus as a truly interdisciplinary problem at the crossroads of neurophysiology, neuroimmunology, neuropharmacology, protease research, internal medicine, and dermatology, which is combated most successfully if one keeps the multilayered nature of 'itch' in mind and adopts a holistic treatment approach - beyond the customary, frequently frustrane monotherapy with histamine receptor antagonists. In view of the often unsatisfactory, unidimensional, and altogether rather crude standard instruments for pruritus management that we still tend to use in clinical practice today, an interdisciplinary team of pruritus experts here critically examines recent progress in pruritus research that future itch management must take into consideration. Focusing on new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus, and discussing available neuropharmacological tools, specific research avenues are highlighted, whose pursuit promises to lead to novel, and hopefully more effective, forms of pruritus management.},
  author       = {Biro, T and Ko, M C and Bromm, B and Wei, E T and Bigliardi, P and Siebenhaar, F and Hashizume, H and Misery, L and Bergasa, N V and Kamei, C and Schouenborg, Jens and Roostermann, D and Szabo, T and Maurer, M and Bigliardi-Qi, M and Meingassner, J G and Hossen, M A and Schmelz, M and Steinhoff, M},
  issn         = {0906-6705},
  language     = {eng},
  number       = {3},
  pages        = {225--225},
  publisher    = {Wiley-Blackwell},
  series       = {Experimental Dermatology},
  title        = {How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches},
  url          = {http://dx.doi.org/10.1111/j.0906-6705.2005.0321a.x},
  volume       = {14},
  year         = {2005},
}