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Postnatal appearance of 5-HT2A receptors on fast flexor and slow extensor rat motor neurons

Vult von Steyern, Fredrik LU and Lomo, T (2005) In Neuroscience 136(1). p.87-93
Abstract
Motor neurons to the slowly contracting extensor soleus muscle in behaving rats begin to fire tonically in the 2nd week after birth. In the adult, tonic firing becomes predominant and appears to arise from plateau potentials under monoaminergic control. In the present work, motor neurons to slowly contracting extensor soleus and rapidly contracting extensor digitorum longus, a physiological flexor muscle, were retrogradely labeled with fluorescent dextran and examined for immunoreactivity to 5-HT(2A) receptors in 1 and 2 week old and adult rats. No reactivity was detected at 1 week. At 2 weeks, reactivity was detected on 67% slowly contracting extensor soleus (16 of 24) and 19% extensor digitorum longus (11 of 57) motor neurons. In the... (More)
Motor neurons to the slowly contracting extensor soleus muscle in behaving rats begin to fire tonically in the 2nd week after birth. In the adult, tonic firing becomes predominant and appears to arise from plateau potentials under monoaminergic control. In the present work, motor neurons to slowly contracting extensor soleus and rapidly contracting extensor digitorum longus, a physiological flexor muscle, were retrogradely labeled with fluorescent dextran and examined for immunoreactivity to 5-HT(2A) receptors in 1 and 2 week old and adult rats. No reactivity was detected at 1 week. At 2 weeks, reactivity was detected on 67% slowly contracting extensor soleus (16 of 24) and 19% extensor digitorum longus (11 of 57) motor neurons. In the adult, the intensity of staining was higher and the percentage of labeled motor neurons 79 for slowly contracting extensor soleus (34 of 43) and 31 for extensor digitorum longus (11 of 35). On slowly contracting extensor soleus motor neurons, labeling appeared more often on soma and dendrites than on dendrites only, whereas on extensor digitorum longus motor neurons, labeling appeared more often on dendrites only. These results are consistent with the hypothesis that serotonergic innervation contributes to the appearance and subsequent increase in tonic firing of rat slowly contracting extensor soleus motor neurons in postnatal development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
5-HT2A receptors, motor neurons, motor control, motor development, tonic activity, plateau potentials
in
Neuroscience
volume
136
issue
1
pages
87 - 93
publisher
Elsevier
external identifiers
  • pmid:16203096
  • scopus:26944437056
ISSN
1873-7544
DOI
10.1016/j.neuroscience.2005.07.059
language
English
LU publication?
yes
id
5e92dc42-d3b9-48c3-a88f-898b7ed2efad (old id 1133813)
date added to LUP
2008-06-17 12:58:53
date last changed
2017-01-01 05:12:50
@article{5e92dc42-d3b9-48c3-a88f-898b7ed2efad,
  abstract     = {Motor neurons to the slowly contracting extensor soleus muscle in behaving rats begin to fire tonically in the 2nd week after birth. In the adult, tonic firing becomes predominant and appears to arise from plateau potentials under monoaminergic control. In the present work, motor neurons to slowly contracting extensor soleus and rapidly contracting extensor digitorum longus, a physiological flexor muscle, were retrogradely labeled with fluorescent dextran and examined for immunoreactivity to 5-HT(2A) receptors in 1 and 2 week old and adult rats. No reactivity was detected at 1 week. At 2 weeks, reactivity was detected on 67% slowly contracting extensor soleus (16 of 24) and 19% extensor digitorum longus (11 of 57) motor neurons. In the adult, the intensity of staining was higher and the percentage of labeled motor neurons 79 for slowly contracting extensor soleus (34 of 43) and 31 for extensor digitorum longus (11 of 35). On slowly contracting extensor soleus motor neurons, labeling appeared more often on soma and dendrites than on dendrites only, whereas on extensor digitorum longus motor neurons, labeling appeared more often on dendrites only. These results are consistent with the hypothesis that serotonergic innervation contributes to the appearance and subsequent increase in tonic firing of rat slowly contracting extensor soleus motor neurons in postnatal development.},
  author       = {Vult von Steyern, Fredrik and Lomo, T},
  issn         = {1873-7544},
  keyword      = {5-HT2A receptors,motor neurons,motor control,motor development,tonic activity,plateau potentials},
  language     = {eng},
  number       = {1},
  pages        = {87--93},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Postnatal appearance of 5-HT2A receptors on fast flexor and slow extensor rat motor neurons},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2005.07.059},
  volume       = {136},
  year         = {2005},
}