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Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children

Roberton, D; Marshall, H; Nolan, T M; Sokal, E; Diez-Domingo, J; Flodmark, Carl-Erik LU ; Rombo, L; Lewald, G; Flor Jde, L and Casanovas, J M, et al. (2005) In Vaccine 23(43). p.5099-5105
Abstract
This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least... (More)
This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7). (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hepatitis A and B, Combined vaccine, Children
in
Vaccine
volume
23
issue
43
pages
5099 - 5105
publisher
Elsevier
external identifiers
  • scopus:24944456745
ISSN
1873-2518
DOI
10.1016/j.vaccine.2005.06.003
language
English
LU publication?
no
id
1a0004b3-e604-4aae-aa3c-712d67c69dd0 (old id 1134102)
date added to LUP
2008-06-18 11:56:36
date last changed
2017-01-01 05:07:29
@article{1a0004b3-e604-4aae-aa3c-712d67c69dd0,
  abstract     = {This study was conducted to compare the reactogenicity, immunogenicity and safety of a combined two-dose (0, 6 months) hepatitis A and B vaccine (720ELU HAV, 20 mcg HBsAg) with the established three-dose (0, 1 and 6 months) hepatitis A and B vaccine (360ELU HAV, 10 mcg HBsAg). A total of 511 children aged 1-11 years who had not previously received a hepatitis A or B vaccine were enrolled in the study. Both vaccines were well tolerated, and were shown to be safe and immunogenic. The analysis, stratified according to two age groups (1-5 year and 6-11-year-old children) demonstrated that the reactogenicity profile of the two-dose schedule was at least as good as that of the established schedule. Both vaccines and schedules provided at least 98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A, 1 month after the end of the vaccination course (Month 7).},
  author       = {Roberton, D and Marshall, H and Nolan, T M and Sokal, E and Diez-Domingo, J and Flodmark, Carl-Erik and Rombo, L and Lewald, G and Flor Jde, L and Casanovas, J M and Verdaguer, J and Mares, J and Esso, D V and Dieussaert, I and Stoffel, M},
  issn         = {1873-2518},
  keyword      = {Hepatitis A and B,Combined vaccine,Children},
  language     = {eng},
  number       = {43},
  pages        = {5099--5105},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2005.06.003},
  volume       = {23},
  year         = {2005},
}