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Chromatin, epigenetics and stem cells

Roloff, Tim C and Nuber, Ulrike LU (2005) In European Journal of Cell Biology 84(2-3). p.123-135
Abstract
Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Stem cells, Epigenetics, Chromatin, Histone modification, DNA methylation, Gene expression
in
European Journal of Cell Biology
volume
84
issue
2-3
pages
123 - 135
publisher
Elsevier
external identifiers
  • pmid:15819395
  • scopus:14844357911
ISSN
0171-9335
DOI
10.1016/j.ejcb.2004.12.013
language
English
LU publication?
yes
id
d6e26dcf-6be1-4ac3-a8ef-e4d731597cca (old id 1134243)
date added to LUP
2008-06-18 08:32:21
date last changed
2017-09-10 03:38:56
@article{d6e26dcf-6be1-4ac3-a8ef-e4d731597cca,
  abstract     = {Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control.},
  author       = {Roloff, Tim C and Nuber, Ulrike},
  issn         = {0171-9335},
  keyword      = {Stem cells,Epigenetics,Chromatin,Histone modification,DNA methylation,Gene expression},
  language     = {eng},
  number       = {2-3},
  pages        = {123--135},
  publisher    = {Elsevier},
  series       = {European Journal of Cell Biology},
  title        = {Chromatin, epigenetics and stem cells},
  url          = {http://dx.doi.org/10.1016/j.ejcb.2004.12.013},
  volume       = {84},
  year         = {2005},
}