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Involvement of sympathetic nerve activity in skin blood flow oscillations in humans.

Söderström, Torbjörn LU ; Stefanovska, Aneta; Veber, Mitja and Svensson, Henry LU (2003) In American Journal of Physiology: Heart and Circulatory Physiology 284(5). p.1638-1646
Abstract
We have used the wavelet transform to evaluate the time-frequency content of laser-Doppler flowmetry (LDF) signals measured simultaneously on the surfaces of free microvascular flaps deprived of sympathetic nerve activity (SNA), and on adjacent intact skin, in humans. It was thereby possible to determine the frequency interval within which SNA manifests itself in peripheral blood flow oscillations. The frequency interval from 0.0095 to 2 Hz was examined and was divided into five subintervals: I, ~0.01 Hz; II, ~0.04 Hz; III, ~0.1 Hz; IV, ~0.3 Hz; and V, ~1 Hz. The average value of the LDF signal in the time domain as well as the mean amplitude and total power in the interval from 0.0095 to 2 Hz and amplitude and power within each of the... (More)
We have used the wavelet transform to evaluate the time-frequency content of laser-Doppler flowmetry (LDF) signals measured simultaneously on the surfaces of free microvascular flaps deprived of sympathetic nerve activity (SNA), and on adjacent intact skin, in humans. It was thereby possible to determine the frequency interval within which SNA manifests itself in peripheral blood flow oscillations. The frequency interval from 0.0095 to 2 Hz was examined and was divided into five subintervals: I, ~0.01 Hz; II, ~0.04 Hz; III, ~0.1 Hz; IV, ~0.3 Hz; and V, ~1 Hz. The average value of the LDF signal in the time domain as well as the mean amplitude and total power in the interval from 0.0095 to 2 Hz and amplitude and power within each of the five subintervals were significantly lower for signals measured on the free flap (P < 0.002). The normalized spectral amplitude and power in the free flap were significantly lower in only two intervals: I, from 0.0095 to 0.021 Hz; and II, from 0.021 to 0.052 Hz (P < 0.05); thus indicating that SNA is manifested in at least one of these frequency intervals. Because interval I has recently been shown to be the result of vascular endothelial activity, we conclude that we have identified SNA as influencing blood flow oscillations in normal tissues with repetition times of 20-50 s or frequencies of 0.02-0.05 Hz. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoregulation, wavelet transform, blood flow variability, time-frequency analysis, microvascular free flaps
in
American Journal of Physiology: Heart and Circulatory Physiology
volume
284
issue
5
pages
1638 - 1646
publisher
American Physiological Society
external identifiers
  • pmid:12679328
  • wos:000182023400019
  • scopus:0345700663
ISSN
1522-1539
DOI
language
English
LU publication?
yes
id
fa138f1d-d060-4138-a193-6b17784a91a8 (old id 113546)
alternative location
http://ajpheart.physiology.org/cgi/content/abstract/284/5/H1638
date added to LUP
2007-07-30 15:33:04
date last changed
2018-06-03 03:43:52
@article{fa138f1d-d060-4138-a193-6b17784a91a8,
  abstract     = {We have used the wavelet transform to evaluate the time-frequency content of laser-Doppler flowmetry (LDF) signals measured simultaneously on the surfaces of free microvascular flaps deprived of sympathetic nerve activity (SNA), and on adjacent intact skin, in humans. It was thereby possible to determine the frequency interval within which SNA manifests itself in peripheral blood flow oscillations. The frequency interval from 0.0095 to 2 Hz was examined and was divided into five subintervals: I, ~0.01 Hz; II, ~0.04 Hz; III, ~0.1 Hz; IV, ~0.3 Hz; and V, ~1 Hz. The average value of the LDF signal in the time domain as well as the mean amplitude and total power in the interval from 0.0095 to 2 Hz and amplitude and power within each of the five subintervals were significantly lower for signals measured on the free flap (P &lt; 0.002). The normalized spectral amplitude and power in the free flap were significantly lower in only two intervals: I, from 0.0095 to 0.021 Hz; and II, from 0.021 to 0.052 Hz (P &lt; 0.05); thus indicating that SNA is manifested in at least one of these frequency intervals. Because interval I has recently been shown to be the result of vascular endothelial activity, we conclude that we have identified SNA as influencing blood flow oscillations in normal tissues with repetition times of 20-50 s or frequencies of 0.02-0.05 Hz.},
  author       = {Söderström, Torbjörn and Stefanovska, Aneta and Veber, Mitja and Svensson, Henry},
  issn         = {1522-1539},
  keyword      = {autoregulation,wavelet
transform,blood flow variability,time-frequency analysis,microvascular free flaps},
  language     = {eng},
  number       = {5},
  pages        = {1638--1646},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Heart and Circulatory Physiology},
  title        = {Involvement of sympathetic nerve activity in skin blood flow oscillations in humans.},
  url          = {http://dx.doi.org/},
  volume       = {284},
  year         = {2003},
}