Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The effect of continuous HRT on glucose homeostasis and plasma lipids. A placebo-controlled study in postmenopausal women with type 2 diab

Thunell, Louise LU ; Adersson, B ; Glassell, M and Mattsson, L-A (2006) In Maturitas 53(4). p.430-438
Abstract
Background



Hyperandrogenicity in women is a risk factor for cardiovascular disease and noninsulin-dependent diabetes mellitus (NIDDM). Estradiol alone decreases hyperandrogenicity and have beneficial effects on glucose metabolism and plasma lipids in postmenopausal women with type 2 diabetes.

Objectives



To analyse effects on glucose homeostasis and plasma lipids by 2 mg estradiol and 1 mg norethisterone acetate (NETA) given as a daily tablet during 6 months in postmenopausal women with type 2 diabetes.

Design



Randomised, double-blind, placebo-controlled, cross-over design.

Material and methods



Thirty-one postmenopausal women with type 2... (More)
Background



Hyperandrogenicity in women is a risk factor for cardiovascular disease and noninsulin-dependent diabetes mellitus (NIDDM). Estradiol alone decreases hyperandrogenicity and have beneficial effects on glucose metabolism and plasma lipids in postmenopausal women with type 2 diabetes.

Objectives



To analyse effects on glucose homeostasis and plasma lipids by 2 mg estradiol and 1 mg norethisterone acetate (NETA) given as a daily tablet during 6 months in postmenopausal women with type 2 diabetes.

Design



Randomised, double-blind, placebo-controlled, cross-over design.

Material and methods



Thirty-one postmenopausal women with type 2 diabetes, glycosylated haemoglobin (HbA1c) of 6% or more and sex hormone-binding globulin (SHBG) values of 60 nmol/L or less were included. Anthropometric variables, blood pressure, sex steroid hormones, HbA1c, serum and lipoprotein lipids, plasminogen activator inhibitor 1 (PAI-1) and insulin-like growth factor 1 (IGF-1) were measured. An oral glucose tolerance test (OGTT) was performed and blood glucose, insulin and C-peptide were analysed. All measurements were taken at baseline and after each 6-month period.

Results



An increase of SHBG and a decrease in free testosterone and PAI-1 levels was induced by the estradiol/NETA treatment compared with placebo. Lipoprotein(a) decreased but otherwise lipid metabolism was unaffected. No differences were recorded in glucose homeostasis between active treatment and placebo.

Conclusion



Estradiol/NETA therapy decreased hyperandrogenicity in postmenopausal women with type 2 diabetes. Lipoprotein(a) and PAI-1 which are independent risk factors for coronary heart disease decreased. No changes in glucose homeostasis were found. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hormone replacement therapy, Type 2 diabetes, Glucose homeostasis, Lipids, Postmenopausal women, PAI-1
in
Maturitas
volume
53
issue
4
pages
430 - 438
publisher
Elsevier
external identifiers
  • scopus:33644635448
ISSN
1873-4111
DOI
10.1016/j.maturitas.2005.07.008
language
English
LU publication?
yes
id
2e6d5538-1490-4dcb-9c4f-2d15f136fc0e (old id 1136188)
date added to LUP
2016-04-01 12:17:29
date last changed
2021-02-17 05:49:06
@article{2e6d5538-1490-4dcb-9c4f-2d15f136fc0e,
  abstract     = {Background<br/><br>
<br/><br>
Hyperandrogenicity in women is a risk factor for cardiovascular disease and noninsulin-dependent diabetes mellitus (NIDDM). Estradiol alone decreases hyperandrogenicity and have beneficial effects on glucose metabolism and plasma lipids in postmenopausal women with type 2 diabetes.<br/><br>
Objectives<br/><br>
<br/><br>
To analyse effects on glucose homeostasis and plasma lipids by 2 mg estradiol and 1 mg norethisterone acetate (NETA) given as a daily tablet during 6 months in postmenopausal women with type 2 diabetes.<br/><br>
Design<br/><br>
<br/><br>
Randomised, double-blind, placebo-controlled, cross-over design.<br/><br>
Material and methods<br/><br>
<br/><br>
Thirty-one postmenopausal women with type 2 diabetes, glycosylated haemoglobin (HbA1c) of 6% or more and sex hormone-binding globulin (SHBG) values of 60 nmol/L or less were included. Anthropometric variables, blood pressure, sex steroid hormones, HbA1c, serum and lipoprotein lipids, plasminogen activator inhibitor 1 (PAI-1) and insulin-like growth factor 1 (IGF-1) were measured. An oral glucose tolerance test (OGTT) was performed and blood glucose, insulin and C-peptide were analysed. All measurements were taken at baseline and after each 6-month period.<br/><br>
Results<br/><br>
<br/><br>
An increase of SHBG and a decrease in free testosterone and PAI-1 levels was induced by the estradiol/NETA treatment compared with placebo. Lipoprotein(a) decreased but otherwise lipid metabolism was unaffected. No differences were recorded in glucose homeostasis between active treatment and placebo.<br/><br>
Conclusion<br/><br>
<br/><br>
Estradiol/NETA therapy decreased hyperandrogenicity in postmenopausal women with type 2 diabetes. Lipoprotein(a) and PAI-1 which are independent risk factors for coronary heart disease decreased. No changes in glucose homeostasis were found.},
  author       = {Thunell, Louise and Adersson, B and Glassell, M and Mattsson, L-A},
  issn         = {1873-4111},
  language     = {eng},
  number       = {4},
  pages        = {430--438},
  publisher    = {Elsevier},
  series       = {Maturitas},
  title        = {The effect of continuous HRT on glucose homeostasis and plasma lipids. A placebo-controlled study in postmenopausal women with type 2 diab},
  url          = {http://dx.doi.org/10.1016/j.maturitas.2005.07.008},
  doi          = {10.1016/j.maturitas.2005.07.008},
  volume       = {53},
  year         = {2006},
}